Dhanya B. Sen

Sumandeep Vidyapeeth Deemed to be University · Department of Pharmacy

Combination treatment enhances efficacy, minimizes side effects, and improves convenience for patients with diverse treatment schedules. This compilation focuses on the simultaneous estimation of Miconazole nitrate (MNE), Mupirocin (MRN), and Mometasone furoate (MMT) using HPLC and HPTLC in an ointment which is wisely used combination for treatment...

A combination of fixed dose tablet containing 0.5 mg lobeglitazone sulfate (LBZ) and 1 mg glimepiride (GLM) has demonstrated efficacy in enhancing glycemic control in diabetes. The projected work aimed to develop and validate a high‐performance thin‐layer chromatographic (HPTLC) methodology for the precise quantification of both the drugs in tablet...

Green chemistry, a rapidly evolving discipline, aims to design chemical processes and products that minimize environmental impact while maximizing efficiency and sustainability. This paper provides an overview of the principles and practices of green chemistry, emphasizing the importance of atom economy, renewable feedstocks, energy efficiency, and...

In the study simultaneous assessment of teneligliptin hydrobromide hydrate and metformin hydrochloride in tablets were developed and validated by four new UV spectroscopic approaches. The ratio difference approach was used to measure the variation in two selected amplitudes of ratio spectra, and the regression equation was employed to determine the...

Nowadays, most antiviral drugs are plant-based due to their low toxicity and high resistance. Morinda citrifolia (Noni) is such a perennial shrub a popular plant based medicine due to its wide therapeutic applications. The phytochemicals present in its fruit as well as its leaf have many antiviral properties and can enhance the human immune system....

The current study aims to develop and validate an analytical quality by design approach-based high-performance thin-layer chromatographic (HPTLC) method for the analysis of Axitinib tablet samples. The chromatographic conditions in the TLC method were optimized using a three-level full factorial design. The mobile phase composition and chamber satu...

In recent years, interest in antioxidant properties of green tea (Camellia sinensis) has increased in Western nations, despite the fact that the beverage itself is thousands of years old and originated in China. Numerous deaths all around the world can be attributed to cardiovascular disease (CVD), often called as heart and vascular ailment. Catech...

The irregular electrical activity of the heart causes an illness known as arrhythmia. Heart ailments are the foremost cause of mortality and disability across the globe. Regardless of the fact that some anti-arrhythmic medicines have been used in clinical practice for decades, their use is often constrained by the side effects they cause. The ratio...

Diabetes and atherosclerosis are becoming major issues for public health around the world because of their high prevalence and incidence. Atherosclerosis is linked to a higher risk of cardiovascular disease in people with both type 1 and type 2 diabetes mellitus. Compared to people who do not have diabetes, diabetic patients have a significantly in...

A highly effective high-performance thin-layer chromatographic methodology has been developed and validated for the concurrent measurement of teneligliptin hydrobromide hydrate and pioglitazone hydrochloride in tablet offering excellent sensitivity, precision, accuracy, and robustness. The methodology involved using aluminum plates layered with sil...

Enhanced glycemic regulation in individuals with diabetes mellitus can be achieved using a fixed-dose combination of dapagliflozin (10 mg) and vildagliptin (100 mg) in tablet. The primary objective of this research was to develop and validate a high-performance thin layer chromatographic methodology for accurately measuring the quantities of dapagl...

Improved glycemic regulation in people with diabetes mellitus can be achieved with a fixed-dose combination (tablets) comprising dapagliflozin 10 mg and vildagliptin 100 mg. The proposed research suggests five spectrophotometric methodologies namely simultaneous equation, absorbance ratio, second derivative zero crossing, ratio difference, and f...

The fixed-dose combination (tablets) Remo® MV 500, consists of remogliflozin (RGF), vildagliptin (VGT), and metformin hydrochloride (MTH), enhances blood sugar regulation in people having diabetes mellitus (type 2). The proposed study introduces four newer spectrophotometric approaches for the concurrent assessment of the fixed dosage form that...

A straightforward RP-HPLC approach has been developed and validated for the simultaneous estimation of drotaverine hydrochloride (DROTA) and diclofenac potassium (DICLO) in their combined dosage form. This method was found to be simple, accurate, and precise. Chromatographic detection has been carried out on a Phenomenex C18 column (250 mm × 4.6 mm...

Background and Aim: Tablets containing celecoxib and tramadol hydrochloride that are sold under the brand name Seglentis® have given approval by the “Food and Drug Administration” (FDA) for the treatment of adults suffering from acute pain. Simultaneous assessment of celecoxib and tramadol hydrochloride in synthetic mixture was performed by five...

Introduction: Fungal infection remains a continuous and growing threat to human health. Combination therapy may be an optional approach for the treatment of invasive fungal infections, and the potential antifungal mechanisms provide new insights into novel antifungal drug development. Several papers have proven that blend of miconazole nitrate and...

For the purpose of analyzing empagliflozin, a stability indicating high performance thin layer chromatographic method was developed. This method was optimized using design of experiment. In order to optimize the process, independent variables such as the proportion of isopropyl alcohol in the mobile phase, the duration of time that the chamber was...

The medical disorder known as hyperlipidemia is characterized by unusually high amount of lipids in the blood (fatty substances). This illness is also associated with being overweight. Even though hypolipidemic drugs are commonly used to treat cardiovascular diseases and stroke, there is a possibility that they may cause undesirable side effects. M...

Herbal remedies, often known as herbal medicine or botanical medicine, are natural treatments that make use of the therapeutic capabilities of plants and plant-based extracts. Due to their apparent efficacy and lack of negative side effects, these treatments have been practiced for centuries in numerous civilizations all over the world. The usage o...

ABSTRACT Background and Aim: Qternmet XR ® consisting of dapagliflozin (10 mg), saxagliptin (5 mg),and metformin hydrochloride (1000 mg), is a fixed-dose combination (tablets) that improvesglycemic control in individuals with diabetes mellitus (type 2). The projected work presents fourspectrophotometric methods that are eco-friendly, quick, effortl...

Background and Aim: Qternmet XR ® consisting of dapagliflozin (10 mg), saxagliptin (5 mg), and metformin hydrochloride (1000 mg), is a fixed-dose combination (tablets) that improves glycemic control in individuals with diabetes mellitus (type 2). The projected work presents four spectrophotometric methods that are eco-friendly, quick, effortless, a...

Herbs are one of humanity’s oldest known therapeutic needs for long-term health, and they serve as the foundation for modern medicine. There is currently a thirst and demand for healthy diets with added value all around the world. One such important herb that can be found in many different locations is corn silk. The Chinese and Native Americans ha...

Green pharmaceuticals are demanding popularity globally. In many pharmaceutical formulations, plant-based gums and mucilages are the major ingredients because of their bioavailability, widespread accessibility, non-toxicity, and reasonable prices. The main objective of this study was to isolate and analysis of the mucilage to exhibit the fundamenta...

Abstract: Background and Aim: Trijardy XR® consisting of empagliflozin, linagliptin, and metformin hydrochloride, a fixed-dose combination (tablets) that improves glycemic control in individuals with diabetes mellitus (type 2). The present work presents four spectrophotometric methods that are quick, effortless, accurate and reproducible for the co...

A synthesis of novel 5-Amino-Salicylic Acid derivatives by using 3-methyl-2-thiophenecarboxaldehyde as an starting material and followed by N,N-dicyclohexylcarbodiimide. Further invention relates to the novel 5-Amino-Salicylic Acid derivatives used for anti�inflammatory, analgesic, neuroprotective, and antitumor properties.

A synthesis of novel 5-Amino-Salicylic Acid derivatives by using 3-methyl-2-thiophenecarboxaldehyde as an starting material and followed by N,N-dicyclohexylcarbodiimide. Further invention relates to the novel 5-Amino-Salicylic Acid derivatives used for anti-inflammatory, analgesic, neuroprotective, and antitumor properties

Docking is a crucial tool in molecular design and development because it predicts the supported path of one particle to the next when they are bonded together to form a stable and flighty complex. As a result, information about the supported bearing can be used to estimate the strength of the connection and the binding attraction between a ligand a...

Peptic ulcer is a disorder that commonly has an effect on the digestive system. It is a chronic illness which has impact on approximately, 10% of the mankind. The majority of current therapy regimens are based on western medicine. Proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, which are commonly used to treat peptic ulcers...

Flavonoids are a sort of natural substance which are basically plant secondary metabolites having a polyphenolic structure present in a wide range of food products. Flavonoids have become a vital constituent in nutraceutical, pharmacological, therapeutic, and cosmetic fields. This is owing to their capability to regulate essential cellular enzyme a...

The present work describes three spectrophotometric methods for determining two phytoconstituent berberine hydrochloride and eugenol in formulated gels: simultaneous equation method, absorbance correction, and zero-crossing derivative method. In the simultaneous equation method, the absorbance at 263 nm and 280 nm and the absorbance correction meth...

Diabetes is one of the main disease having many repercussions due to which there is a huge economic burden globally. Therefore, there is a need of good therapeutic intervention by using some nutraceuticals to combat this dreadful disease especially complications such as diabetic neuropathy where patients suffer from severe pain and disability. T...

A stability indicating reversed-phase high-performance liquid-chromatographic method for analysis of empagliflozin was developed and validated as per the ICH guidelines. Statistical design of experiment was applied for optimization, where independent variables used were methanol proportions in mobile phase and flow rate. Experiment was carried out...

Aim: A simple, accurate, precise, and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous assessment of alogliptin benzoate (ALO) and metformin hydrochloride (MET) in combined tablet formulation. Materials and Methods: The proposed RP-HPLC method employed a reverse phase colu...

Introduction: Three new UV spectrophotometric approaches specifically, simultaneous equation (SME), absorbance ratio (ASR), and first derivative (zero crossing) spectroscopic techniques were developed and validated for simultaneous estimation of luliconazole (LCZ) and gallic acid (GLA) in emulgel formulation which were simple, sensitive, precise, a...

Background Several computer-aided drug design (CADD)methods enable the design and development of novel chemical entities.Structure-based drug design (SBDD) and the knowledge of in silico methods enable the visualization of the binding process of ligands to targets and to predict the key binding pocket sites and affinity of ligands to their target m...

Nowadays, nanotechnology is receiving worldwide recognition due to being its applications in various fields. Medium temperature and eco-friendly methods have shown great potential among nanoparticle synthesis. Many reducing agents are available for the synthesis of ZnO nanoparticles; here we presented a simple solution method for the development of...

Background: For a cardiovascular patient's blood pressure to be effectively controlled, more than one drug is required. When coupled with amlodipine besylate (AMLO), a calcium channel blocker, Aliskiren hemifumarate (ALI) is the 1 st nonpeptide, low molecular mass, orally active transition state rennin inhibitor to efficaciously normalize blood pre...

Three new, precise, accurate and sensitive UV-Spectrophotometric methods namely Ratio Difference Spectroscopic Method (RDSM), First Derivative of Ratio Spectra Method (DR1) and Area Under Curve Method (AUC) were developed and validated for simultaneous assessment of alogliptin benzoate (ALO) and pioglitazone hydrochloride (PIO) in tablet dosage for...

Adiponectin is a most abundant secretory protein produced by adipocytes of white adipose tissue. Adiponectin circulates in blood as three different (high-molecular, middle-molecular, and low-molecular weight) isoforms, gives its effects through AdipoR1 and AdipoR2 receptor. Primary data suggesting that adiponectin has insulin-sensitizing, anti-athe...

Throughout the globe, nanotechnology has emerged as a segment which produces a multitrillion-dollar business opportunity that covers a wide range of industries such as medicine, electronics, and chemistry. Due to the rapid development of application-oriented nanoparticles, from targeted drug delivery to diagnostics, in vivo toxicological examinatio...

ABSTRACT Background and Aim: The proposed work was planned to evaluate the potential protective role of aqueous Aloe vera (AV) concentrate and/or Omega-3 fatty acids (O3FAs) against GM -initiated renal toxicity in rats. Materials and Methods: Thirty female Wistar-albino rats were distributed into five equivalent groups as follows: Normal control gr...

Flavonoids are natural products, more precisely secondary metabolites with low molecular weight produced by plants. Unlike primary metabolites, they are non-essential for plant survival. These secondary metabolites are biologically active and more than 10,000 structural variants of flavonoids have been reported such as flavonols, flavones, flavanon...

Objective: To develop and validate a simple and sensitive RP-HPLC method for the simultaneous determination of mometasone furoate (MOM) and formoterol fumarate (FOR) in pharmaceutical dosage forms. Methods: In RP-HPLC method, chromatographic separation was achieved using a mixture of a solvent system consisting of methanol–water (pH 3.5) in the rat...

Three simple, sensitive, precise and accurate UV-spectroscopic methods namely simultaneous equation, absorbance ratio and first derivative (zero crossing) spectroscopic methods were developed and validated for simultaneous determination of aliskiren hemifumarate and hydrochlorothiazide in tablet dosage form. Simultaneous equation method was based o...

Three new UV spectrophotometric methods namely simultaneous equation, absorbance ratio and first derivative (zero crossing) spectroscopic methods were developed and validated for simultaneous estimation of teneligliptin hydrobromide hydrate and metformin hydrochloride in tablet formulation which were simple, sensitive, precise and accurate. In simu...

Statins have anti-inflammatory effects that are not directly related to their cholesterol lowering activity. This study was carried out to evaluate the effect of simvastatin or rosuvastatin on the extent of colonic mucosal damage and on the inflammatory response in trinitrobenzene sulfonic acid (TNBS)-induced ulcerative colitis. Ulcerative colitis...

Objective: Development and validation of quantitative simultaneous determination of aliskiren hemifumarate (ALI) and hydrochlorothiazide (HCT) in combined tablet formulation by RP-HPLC. Methods: The separation of components were achieved on Enable C18 column (250×4.6 mm, 5 μm) with a mobile phase consisting of 0.2%v/v triethylamine in water (pH 6 w...

Objective: Development and validation of two simple, rapid, accurate and sensitive UV-spectrophotometric methods for simultaneous estimation of alogliptin benzoate (ALO) and metformin hydrochloride (MET) in bulk and tablet dosage form. Methods: First method (Method A) is simultaneous equation method, which is based on the measurement of absorption...

A simple, precise and rapid RP-HPLC method was developed for the determination of doxazosin mesylate in pharmaceutical formulations. The method was carried out on a Chromolith RP-C(18) column using a mixture of potassium phosphate buffer and methanol (40:60 v/v) and detection was done at 251 nm. The linearity range was 1-5 μg/ml. The retention time...

Single drop micro extraction (SDME) has emerged over the last 10-15 years as one of the simplest and most easily implemented forms of micro-scale sample cleanup and preconcentration. In the most common arrangement, an ordinary chromatography syringe is used to suspend micro liter quantities of extracting solvent either directly immersed in the samp...

Some new 2-[(3-methyl-1H-indazol-1-yl)-3-substituted phenyl-1, 8-naphthyridine have been synthesized employing microwave techiniques and evaluated for antimicrobial activity. 3-aryl-2-hydrazino-1, 8-naphthyridines (1) were reacted with Substituted acetophenones (2) in the presence of methanol to furnish 2-{(2E)-2-[1-(2-chlorophenyl) ethylidene] hyd...

The development of resistance to current antibacterial therapy continues to drive the search for more effective agents. The chemistry, synt hesis and biology of the 2-azetidinone pharmacophore continues to be fuelled by their wide range of biological properties such as antibacterial [1], anticonvulsant [2], antihyperglycemic, antitumour, anti-HIV,...

Ten Novel compounds have been synthesized combining Phenothiazine ring and Benzimidazole. Phenothiazine (I) was synthesized by reacting diphenylamine, sulfur, and iodine which subsequently reacted with p-amino benzoic acid and aromatic aldehydes in ethanol produces 10-(α-p-carboxyphenylaminobenzyl) phenothiazines (II). Phenothiazines (II) was furth...

The increasing clinical importances of drug resistant bacterial and fungal pathogens have lent an additional urgency in the field of microbiological research and development of new antimicrobial comTpounds. Microwave assisted synthesis is less time consuming and environmental friendly as compared to the existing conventional method of synthesis. Py...

In order to support drug discovery and development studies within the pharmaceutical industry there has been an increased use of innovative bioanalytical assays and associated analytical technology. Performing quantitative bioanalysis in a variety of biological matrices can also involve the use of sample preparation techniques, complex HLPC column...