Dipti Gohil

Sumandeep Vidyapeeth University · Department of Pharmacy

Green chemistry, a rapidly evolving discipline, aims to design chemical processes and products that minimize environmental impact while maximizing efficiency and sustainability. This paper provides an overview of the principles and practices of green chemistry, emphasizing the importance of atom economy, renewable feedstocks, energy efficiency, and...

This comprehensive review explores the multifaceted landscape of rheumatoid arthritis (RA), encompassing its epidemiology, pathophysiology, clinical manifestations, diagnosis, treatment approaches, and the impact on patients' quality of life. The review delves into the global prevalence of RA, demographic patterns, and associated risk factors, shed...

This comprehensive review explores the multifaceted landscape of rheumatoid arthritis (RA), encompassing its epidemiology, pathophysiology, clinical manifestations, diagnosis, treatment approaches, and the impact on patients' quality of life. The review delves into the global prevalence of RA, demographic patterns, and associated risk factors, shed...

A UV-visible spectrophotometric method for quantifying tacrolimus in nanoparticles has been developed and validated, and it is accurate, simple, reproducible, and affordable. For drug analysis, optimal conditions have been identified. 291 nm was discovered to be the maximum wavelength (max). In the range of 0.2-1.8 mg/ml, the response was linear (r...

Niosomes are vesicles, which are formulated by hydrating the mixture of cholesterol, non-ionic surfactant and other biodegradable lipids. Niosomes increase the drug activity as compare to their conventional dosage form of a drug. Niosomes can be used as carrier of amphiphilic and lipophilic drugs. Niosomes may overcome the issues related to instabi...

Serum albumin, often referred to simply as albumin, is a globular protein that in humans is encoded by the ALB gene. Albumin is a multifaceted, highly soluble, stable, nontoxic, non-poisonous, biocompatible and biodegradable plasma protein. Albumin has been widely studied as a protein carrier for drug delivery. Because of its versatile nature, it c...

Central nervous system (CNS) disorder is the world’s leading cause of disability and account of more hospitalizations. Central nervous system disorders are a group of neurological disorder that affect the structure or function of the brain or spinal cord. Depression (major depressive disorder or clinical depression) is a common but serious mood dis...

Microsponge is developing field of technology which can achieve goal of site specific as well as controlled drug delivery. Physicochemical properties of microsponge like Particle size, particle size distribution, porosity, surface morphology plays a major role in selection of type of dosage form and route of administration for delivery of drug. Mic...

A suitable drug delivery is an essential element in achieving efficient therapeutic response of drug molecule. Conventional dosage forms have been utilized since several decades but are experiencing certain debilitating issues. Developments of some novel pharmaceutical innovations are required to acquaint into the drug delivery for providing safety...

Protein and peptide are biomolecules that determine and control biological functions, thereby playing a significant role in treating various pathological conditions. Current research focuses on the development of dosage form for efficient delivery of proteins and peptides. Characteristics of biomolecules make them challenging therapeutic agents to...

The present investigation focussed on the development of a novel strategy to enhance the bioavailability of risedronate sodium, which has poor and erratic absorption. Nanosponges were statistically developed by full 32 factorial design using Design of Experiment software considering concentration of polymer and stabilizer as independent variables a...

The objective of present work was to utilize a potential of microemulsion for the improvement in oral bioavailability of raloxifene hydrochloride, a BCS class-II drug with 2% bioavailability. Drug loaded microemulsion was prepared by water titration method using Capmul MCM C8, Tween 20 and Polyethylene glycol 400 as oil, surfactant and co-surfactan...

The aim of the study is to develop a floating microsponges of allopurinol to minimize the frequency of dosing by increasing half life and sustained release action up to 12 hrs by single unit dosage form. Allopurinol is xanthine oxidase inhibitor drug that leads to decrease in the production of uric acid from xanthine and hypoxanthine. It is BCS cla...

The purpose of present research work was to develop spray-dried mucoadhesive microspheres of prochlorperazine (PCPZ) for intranasal administration with an aim to avoid first-pass metabolism and to improve therapeutic effectiveness. A 2 3 factorial design was employed with amount of polymer, feed flow rate and volume of gluteraldehyde as independent...

Pharmaceutical nanoparticles are submicron-sized, colloidal vehicles that carry drugs to the target or release drugs in a controlled way in the body. Controlled drug delivery offers advantages like reduced dosing frequency, better therapeutic control, reduced side effects, and, consequently, better patient compliance. Biodegradable polymers are uti...

Pharmaceutical nanoparticles are submicron-sized, colloidal vehicles that carry drugs to the target or release drugs in a controlled way in the body. Controlled drug delivery offers advantages like reduced dosing frequency, better therapeutic control, reduced side effects, and, consequently, better patient compliance. Biodegradable polymers are uti...

Bambuterol HCl is a potent anti-asthmatic agent, act by stimulation through beta-adrenergic receptors of intracellular adenylcyclase. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. In the present study,...

A simple, rapid and accurate High-performance thin-layer chromatography (HPTLC) method has been established and validated for the simultaneous determination of Lopinavir and Ritonavir in tablets. The method is based on HPTLC separation of the two drugs followed by densitometric measurements of their spots at 266 nm. The separation was carried out o...

Pharmaceutical nanoparticles are submicron-sized, colloidal vehicles that carry drugs to the target or release drugs in a controlled way in the body. Controlled drug delivery offers advantages like reduced dosing frequency, better therapeutic control, reduced side effects, and, consequently, better patient compliance. Biodegradable polymers are uti...

Itraconazole (ITZ) is a synthetic triazole antifungal agent that is active against a broad spectrum of fungal species and effective for the treatment of both systemic fungal infections and superficial mycoses. Sporanox® capsule, oral solution and injection (Janssen Pharmaceutical) are the only commercialized product of itraconazole. The absolute bi...

Itraconazole (ITZ) is a synthetic triazole antifungal agent having topical and systemic efficacy against familiar fungi such as Aspergillus and other filamentous fungi. The difficulties of ITZ with oral administration like dissolution rate limited absorption and gastric side effects can be overcome by formulating it in topical system. The aim of th...

HPMC microspheres of midazolam for nose to brain delivery were developed with the aim to avoid first pass metabolism, to improve the patient compliance, to use an alternative therapy to conventional dosage form, to improve the therapeutic efficacy of midazolam. The purpose of this research was also to formulate and systematically evaluate the perfo...

The polio has been eradicated in most parts of the world, Guillain-Barre syndrome (GBS) has become the most common cause of acute flaccid paralysis. GBS is an autoimmune disorder of the peripheral nervous system characterized by weakness, usually symmetrical, evolving over a period of several days or more. Campylobacter species was isolated from st...

Control chart is the most successful statistical process control (SPC) tool, originally developed by Walter Shewhart in the early 1920s. A control chart can easily collect, organize and store information, calculate answers and present results in easy to understand graphs. It helps to record data and allows to see when an unusual event, e.g., a very...