Imran Ahmad

Integral University

Indoor air quality (IAQ) is significantly impacted by ambient air pollution, and assessing and understanding pollution causes is crucial for developing mitigation plans. The prospect of a "smart environment" using IoT is being explored to improve indoor living conditions. Technological advancements have simplified the design of ambient assisted liv...

This book titled "Basics of Food Chemistry‟ is written for Undergraduate and Postgraduate students as per the new National Education Policy (NEP 2020). This book covers important aspects of Food Chemistry, which is an important branch of science and deals with the study of chemical processes and interactions of all biological and non biological com...

This paper reports a novel green fabrication of copper ferrite (CuFe2O4) nanoparticles (NPs) from Cissus rotundifolia plant extract. The Fourier transforms infrared spectroscopy (FT-IR) spectrum exhibited intrinsic stretching at the tetrahedral position of Fe–O at 591 cm-1 and the octahedral stretching of Cu–O at 402 cm-1 respectively. The fine dif...

A series of amide derivatives of stilbene was synthesized and investigated for osteogenic activity. Out of sixteen, seven compounds viz 19c, 19g, 19i, 24b, 25a, 25c and 26a showed significant osteoblast differentiation within 1pM – 1µM concentrations. Amongst all, 26a was identified as most active molecule which presented effective mineralization o...

A series of conformationally restricted benzopyran based triarylethylenes has been synthesized and characterized as potential growth inhibitors of breast carcinoma cells. The synthesized compounds (14a-b, 15a and 16a-e) presented significant growth inhibition of ER+ and ER- breast cancer cells within the range of IC50 0.55-9.96µM. Amongst other, 16...

3-Arylbenzopyran based non-steroidal osteogenic agents have been explored as structural templates of estrogen and vitamin-D3. The target molecules 18a-c, 19a-c, 26a-c, 27a-c and intermediates 17a-c and 25a-c were studied for their osteogenic activity in an osteoblast differentiation assay in vitro using mouse calvarial osteoblast cells. Compounds 2...

A series of 3,4-diarylbenzopyran based amide derivatives was synthesized and evaluated for osteogenic activity in in vitro and in vivo models of osteoporosis. Compounds 17a, 21b–c and 22a–b showed significant osteogenic activity in osteoblast differentiation assay. Among the synthesized compounds, 22b was identified as lead molecule which showed si...

Development of target oriented chemotherapeutics for treatment of chronic diseases have been considered as an important approach in drug development. Following this approach, in our efforts for exploration of new osteogenic leads, substituted 3-aryl-2H-benzopyran and 3-aryl-3H-benzopyran derivatives (19, 20a-e, 21, 22a-e, 26, 27, 28a-e, 29, 31a-b,...

A new application of BBr3 as a C—C bond forming agent in cyclic ketones, tetralones, chromenone, thiochromenone, and indanones, is investigated.

Syntheses of 2-methoxyestradiol (1) and eugenol (6) template based conformationally flexible and rigid diarylpropenes, 14(a-l) and 20(a-e), as nonsteroidal anticancer agents have been performed. The synthesized compounds were evaluated for their anticancer activity in in-vitro using a panel of human cancer cell lines viz MCF-7, A549, DU 145, KB and...

In our prior studies, we reported some known antitubercular drugs (rifampicin and streptomycin) and newly synthesized chalcone derivatives (16–26) tested in vitro against Mycobacterium tuberculosis H37Rv strain. Most of the tested compounds were efficient antimycobacterial agents showing minimum inhibitory concentration values ranging from 3.5 to 3...

Borontribromide (BBr3) is a well known demethylating agent. Current investigation was focused on a new application of borontribromide as C-C bond forming agent in cyclic ketones. In this study, borontribromide mediated C-C bond formation reactions of tetralones, chromenone, thiochromenone and indanones were explored. Methoxy group containing ketone...

a b s t r a c t Lipophilic chalcones and their conformationally restricted analogues were synthesized and evaluated for their antitubercular efficacy against Mycobacterium tuberculosis H37Rv strain. Compounds 16, 24, 25a and 25c were found to be active MIC at 60, 30, 3.5 and 7.5 lg-mL À1 . In vitro cytotoxicity of compounds 16, 24, 25a, 25c and 26...