Krishna Chandra Panda

Roland Institute of Pharmaceutical Sciences · Department of Pharmaceutical chemistry

In the pursuit of environmental sustainability, the field of green chemistry has emerged as a beacon of hope, offering innovative solutions to mitigate the ecological impact of chemical processes. This abstract explores the symbiotic relationship between green chemistry principles and sustainable practices, elucidating their pivotal role in fosteri...

Background: One of the most widely used chemotherapeutics is methotrexate, a structural counterpart of folic acid, which is particularly useful in haematological malignancies, different solid tumours, and inflammatory illnesses. Objective: Two methotrexate analogues have been synthesized in the current study and are being characterised and biologic...

Medicinal chemistry, at the nexus of chemistry, biology, and pharmacology, continually evolves to address the dynamic landscape of human health challenges. This abstract provides a succinct overview of emerging trends shaping the field of medicinal chemistry, highlighting key advancements, methodologies, and applications that hold promise for revol...

ANTIDIABETICS AND ANTI OXIDANT

Pyrazole scaffolds have emerged as a promising frontier in drug discovery, offering a rich source of chemical diversity and pharmacological activity. This review explores the synthesis, biological significance, medicinal chemistry strategies, computational approaches, recent advances, and future perspectives of pyrazole-based compounds in pharmacot...

The current study focuses on the ability of Balbisia pedunculata methanolic whole plant extract to decrease cholesterol with hyperlipidemia brought on by a high-fat diet. For six weeks, rats were given an oral high-fat diet to produce hyperlipidemia. After that, the extract was given to hyperlipidaemic rats for the next six weeks at two distinct do...

Frontiers in Medicinal Chemistry is a book series devoted to reviews on research topics relevant to medicinal chemistry and allied disciplines. Frontiers in Medicinal Chemistry covers developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug...

Background Molecular docking study is used significantly in the drug discovery process for predicting the interaction between drug and receptor. This technique has been used commonly to identify the binding affinity and orientation of drug molecules at the binding site of the target. The main objectives of docking studies include accurate modeling...

Background: Green strategy involves the design, synthesis, processing, and use of chemical substances by eliminating the generation of chemical hazards. This approach focuses on atom economy, use of safer solvents or chemicals, consumption of energy, and decomposition of the chemical substances to non-toxic materials which are eco-friendly. Objec...

Microwave-assisted chemical reactions are utilized as an emerging tool in drug synthesis as this technique is simple, economic, and efficient. So, a new series of 1,2,4-triazole derivatives are obtained via multi-component reactions under microwave irradiation. First of all, benzohydrazide was obtained by esterification of benzoyl chloride with met...

Green synthetic tools involve the design, synthesis and use of chemical substances by eliminating the generation of chemical hazards. This technique is advantageous in terms of atom economy, use of safer chemicals, energy efficient and decomposition of the waste materials to non-toxic substances which are eco-friendly. So, microwave irradiated heat...

Microwave radiation is used as a heating source during the synthesis of heterocyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis. The microwave hea...

The microwave irradiation method is applied for the efficient synthesis of pyrimidine derivatives. The synthetic protocol involves Knoevenagel condensation followed by Michael addition reaction and cyclization of equimolar quantities of aromatic aldehydes, ethyl cyanoacetate and guanidine in the presence of ethanolic NaOH solution to produce corres...

Multicomponent one-pot synthetic protocol is applied for the efficient preparation of a series of pyrimidine derivative under microwave irradiation method. The synthetic process proceeds via Knoevenagel condensation initially with subsequent Michael addition reaction followed by cyclization of equimolar quantities of substituted bezaldehydes, ethyl...

Green chemistry is also referred as sustainable technology which involves the design, synthesis, processing and use of chemical substances by reducing or eliminating the chemical hazards. This strategy focuses on atom economy, use of safer solvents or chemicals, use of raw materials from renewable resources, consumption of energy and decomposition...

Background Schiff bases play key role for the generation of a large number of biologically active compounds via cycloaddition, replacement and ring closure reactions. Objective The objective of this study is to optimize the purity and yield of product, reaction time, eco-friendly reaction by the help of microwave assisted organic synthesis. Metho...

The synthesis of heterocyclic compounds via carbon-nitrogen (C-N) bond formation reaction is considered as an emerged and efficient protocol in the field of synthetic chemistry. The C–N bond-forming reactions can proceed through condensation, coupling, ring-opening, cyclization or ring closure process etc. The reactivity pattern of these reactions...

The global incidence of cancer and cancer‐related mortality is expected to rise in recent years despite advancements in cancer diagnosis and therapeutics. Increasing evidences of decrypting molecular mechanisms underlying cancer progression have commanded the tremendous development of synthetic anticancer drugs. With limitations in the current conv...

Green synthetic protocol refers to the development of processes for the sustainable production of chemicals and materials. For the synthesis of various biologically active compounds, energy-efficient and environmentally benign processes are applied, such as microwave irradiation technology, ultrasound-mediated synthesis, photo-catalysis (ultraviole...

Boerhavia diffusa (Punarnava) is a famous medicinal plant used in the treatment of l a r ge number of human ailments as mentioned in Ayurveda, Charaka Samhita, and Sushrita Samhita. The whole plant or its parts have a long history of use by Indians and the tribal people. The present work was carried out to evaluate the inhibitory activity of differ...