Chemistry teaching programs have changed little in the last 40 years, despite the fact that both society and chemistry have changed a lot. In this chapter, we reflect on a “chemistry for all” and propose the urgency of definitively changing the orientation of chemistry programs, especially in the stages of basic education. The specific contribution that didactics of science can make to this important reform is analyzed in this chapter, and a well-founded proposal for new “chemistry for all” content in schools and comprehensive chemistry at the University is presented.