Biology - Science topic

Our group are delighted to announce a research topic entitled "Renewed Insight into Cancer Mechanism and Therapy" for publication in Frontiers in Immunology, Frontiers in Physiology, Frontiers in Oncology and Frontiers in medicine.

This topic amis at investigating renewed persipective on biological behavior of cancer, underlying therapeutic target for clinical practice as well as clinical interventions on cancer treatments. We are longing to devote new insights into this area.

We are searching for one or more researchers to participate in this organizing team who meet the following criteria

1. H-index over 15: the researcher should have an H-index greater than 15, which indicates the impact of the corresponding field.

2. No Retracted Publications: the researcher should have a clear record without restracted publications to identify academic integrity.

3. Non-Chinese affiliation: acording to the requirement from Frontiers, the research who is willing to join our group should not belong to any Chinese affiliation owing to team diversity.

This is a special chance to collaborate with outstanding researchers in Caner biology and Cancer therapy.

Responsibilities of collaborators

1. Contribute to frame and conception of research topic

2. Assist in inviting submissions, revewing manuscript and editing content

3. Engage in promotion of the research topic in academic and professional network.

Most of the researchers use to teach at university. In some careers, professionals who exert their profession without doing research share teaching spaces. When I was a chemistry student, 100% of my teachers were researchers ranging from PhD candidates to experts in their respective fields. While it may seem logical for researchers to be the best candidates to teach in fields such as chemistry or biology, what about healthcare-related fields like medicine, pharmacy, or biochemistry? Who is better suited to lead a class, a researcher or a professional, or both, each one in different subjects? We can distinguish between basic and clinical subjects. I am interested in hearing your thoughts on this matter.

What transformative techniques are there in biology?

Dear all,

I want to invite you as a speaker at my department conference, only in Biology field or relevant. Kindly send me a message for the details.

I work in different disciplines (biology, history of science) and would like to list my publications in these field under these categories. Under each category I want to list them by year of publication. Is this possible?

Jitse

Hybridization is a technique used in plant breeding to create new plant varieties by crossing two genetically different parent plants. This process involves transferring pollen from the male reproductive organs of one plant, called the pollen donor or male parent, to the female reproductive organs of another plant, called the female parent. The resulting hybrid plants inherit desirable traits from both parents, such as improved yield, disease resistance, or enhanced quality.

I may be the world's leading expert on parapsychology:

1) http://dx.doi.org/10.13140/RG.2.2.24739.43040

2) https://www.researchgate.net/publication/377663987_Respectfully_and_Unfortunately_The_Improbability_of_and_Danger_in_Believing_in_Reincarnation

Maybe I deserve an honorary PhD in parapsychology. I would then teach afterlife studies @ UC Davis.

Source:

When full empiricism seems to have a foothold and more is sought (no compromises sought) then in the psychological, biological and the social : the Age of Reason may begin .

on

“Multidisciplinary Research”

Date : 17th March 2024

10:00 A.M.

Organized by

Kund Kund Kahan Digambar Jain College, Kota

Kund Kund Kahan Digambar Jain Sanskrit College, Kota

On Virtual Mode

Kund Kund Kahan Digamber Jain College, Kota

09:45 a.m. – 10:00 a.m.

Welcome Note by Dr. Neeraj Sharma , Organizer of International Seminar on Multidisciplinary Research

10:05 a.m. - 10:15 a.m.

Address by Shri Avinash Jain, Secretary, Kund Kund Kahan Digambar Jain Mumukshu Ashram Trust, Kota

10:15 a.m - 10:30 a.m.

10:31 a.m. – 10:40 a.m.

Guest Speaker प्रोफेसर महेंद्र कुमार उपाध्याय, प्राचार्य, कौटिल्य कॉलेज,, कोटा

10:40 a.m.–11:00 a.m.

Guest Speaker प्रोफेसर जितेंद्र तिवारी केरियर पॉइंट यूनिवर्सिटी, कोटा

11:00 a.m.- 11:10 a.m.

Guest Speaker प्रोफेसर मधु कुमार भारद्वाज प्राचार्य हितकारी महिला बी एड कॉलेज, कोटा

11:10 a.m. – 11:20 a.m.

11:20 a.m.–11:40 a.m.

11:40 a.m – 12:00 Noon

12:00 p.m. – 12:20 p.m.

12:20 p.m. onwards

The following candidates have been registered and allowed to present their research paper in International Seminar on Multidisciplinary Research – 2024 organized by Kund Kund Kahan Digambar Jain Sanskrit College ( Approved by Govt.of Rajasthan and Affiliated to Jagatguru Ramanandachary Rajasthan Sanskrit University, Jaipur) and Kund Kund Kahan Digambar Jain College (Affiliated to Kota University, Kota, Rajasthan) Kota, Rajasthan on 17th March 2024.

1

Paper Title

Frames of History: Unveiling the Legacy of Indian Cinema

Authors

Sneha Mamgain, Research Scholar, Mass Communication, Shri Guru Ram Rai University, Dehradun

Dr Rajendra Singh Negi, Assistant Professor, Mass Communication, Shri Guru Ram Rai University, Dehradun

2

Paper Title

Factor affecting mental health of adolescent

Authors

Meenu Verma, Research scholar, University of Rajsthan

3

Paper Title

Impact of COVID -19 on Qualitative Education

Authors

Dr. Jagdish Kumar, Assistant Professor (B.ED), S.G.P.G College , Maltari, Azamgarh (U.P.)

4

Paper Title

Authors

5

Paper Title

Authors

Sneha Rai Priyadarshani, Reserch Scholar, शिबली नेशनल कॉलेज आज़मगढ़

6

Paper Title

Different Dimensions , Problems And Challenges Of Indian Foreign Policy

Authors

Dr. Sonia, Assistant professor in Pol.sci., Om sterling global University Hisar

7

Paper Title

Employment of rural areas

Authors

Babali Yadav, Assistant Professor, V.M.L.G. College Ghaziabad

8

Paper Title

Relationship between constipation and sitting posture. A review

Authors

Dr Mayuri Deshpande , Assistant professor, Mahatma Gandhi Ayurved college hospital and research centre, salod (H), Wardha, Maharashtra, India

9

Paper Title

मध्याह्न भोजन योजना और ग्रामीण क्षेत्र के बच्चों का शिक्षा के प्रति बढ़ता आकर्षण:-एक समाजशास्त्रीय अध्ययन।

Authors

Pratima Singh , Research scholar , D.B.S. COLLEGE KANPUR

10

Paper Title

Comparison of Hand Reaction Ability Among the Different Racket Game Players

Authors

Thokchom Somorjit Singh (PhD), Department of Physical Education and Sports Science. Manipur University, Imphal, India.

Prof. Laishram Thambal Singh (PhD), Professor, Department of Physical Education and Sports Science. Manipur University, Imphal, India.

11

Paper Title

Impact of parenting style on self concept on Adolescent

Authors

Mamta Rani, Ph.d scholar, Department of psychology, Kanya Gurukul kangri Haridwar

Dr.Sunita Rani, Assistant Professor, Department of Psychology, Kanya Gurukul kangri Haridwar

12

Paper Title

उच्च माध्यमिक स्तर पर विद्यालयों में अध्ययनरत विद्यार्थियों की शैक्षिक उपलब्धि पर सांवेगिक बुद्धि का प्रभाव

Authors

Anand Kumar Yaduvanshi, Research Scholar, Veer Bahadur Singh Purvanchal University, Jaunpur

13

Paper Title

Impact of Brand Strategies on Enrollment Decision Making Among Higher Education Universities.

Authors

Ashish Joshi, Ph.D Scholar, SGRRU

14

Paper Title

Age wise Comparison of Life Skills Among 10–12 years Old Students

Authors

Khushboo Godara, Department of Home science, University of Rajasthan. Address: Chainpura, Bhaniyana, Jaisalmer, Pin code 345024

15

Paper Title

Authors

Ms. Seema, PHD scholar, Delhi University, Deptt. Of Education, Working as Lecturer Hindi in the Delhi Government school

16

Paper Title

Diversity of Butterflies in Different Habitat of Kota City

Authors

Dr. Manish Kumar Gupta, M.Sc. (Zoology), M.Phil. (Entomology) Ph.D. (Zoology), Professor & Head Dept. of Biology NISSANSH CLASSES, Former Assit. Professor Zoology Hitkari sahkari mahila shiksha mahavidhyalaya, Dhakadkhedi, Kethun Road Kota

17

Paper Title

Reinterpreting Keats’s “To Autumn” in the Context of Environmental Crisis: Exploring the Poem’s Relevance in Today’s Climate Change.

Authors

M. Julien Mary, - First Author and Corresponding Author Research Scholar, (Reg No.: 2103602004), Department of English, St. joseph University, Ikishe Model Village. Virgin Town, Dimapur, Nagaland

Dr. Thokchom Sunada Devi, Associate Professor and Head of the Department of English. St. Joseph University, Dimapur, Nagaland.

18

Paper Title

Entanglement of the Psyche of Women by Anita Desai in Fasting, Feasting

Authors

Anmol Singh, Ph.D. Research Scholar, Goverment Vidarbha Institute of Science and Humanities, Amravati, Maharashtra

19

Paper Title

Private And Government School’s Education And Children’s Psychosocial Development

Authors

Geeta Kumari, Research Scholar, Department of Psychology, Pataliputra University, Patna

20

Paper Title

An Interplay Between Tradition And Innovation In The Poetry Of Robert Lee Frost

Authors

Swati Sharma, Research Scholar, Vivekananda Global University, Jaipur

21

Paper Title

Efficacy of plasma treated cotton fabric towards washing

Authors

Archana Bahuguna, Department of Textile and Apparel Designing, College of Rural Home Science, Dharwad, University of Agricultural Sciences, Dharwad-580 005, Karnataka, India

22

Paper Title

Navigating the Evolution of Management: Strategies for the Modern Workplace

Authors

Dr. Parveen Sharma, Dean Management, GVM Girls College, Sonipat, Haryana

23

Paper Title

Evolving Recognition: A Study of the Third Gender in Indian Society

Authors

Hemant Kumar, Research Scholar, Raj Rishi Bhartrihari Matsya University Alwar (Rajasthan)

24

Paper Title

Disaster Management in Libraries: Mitigating Risks and Protecting Collections

Authors

Dr. Shibojit Choudhary, Librarian, S. S. College, Hailakandi, Assam

25

Paper Title

An Empirical Study of Women’s Boardroom Representation and Firm Performance in India and Developed Countries

Authors

Apurva Singh, ‘Research Scholar’, Department of Economics, Faculty of Social Sciences, Banasthali Vidyapeeth, Rajasthan - 304022, India

26

Paper Title

Indian aromatic medicinal plant extracts as potential mosquito larvicides

Authors

Dr. Prejwltta Maurya*, Assistant professor, Department of Zoology, Faculty of Science Government Degree College, Targawan, Jaithra, Etah (UP)

27

Paper Title

Indigenous Sustainable Resource Management Resources

Authors

Dr.Brajnath Pandey, Assistant Professor, Atarra P.G.College Atarra Banda U.P.

28

Paper Title

Authors

Geeta Singh, Research Scholar, Government Veerangna Avantibai Lodhi College, Pathariya, Mungeli, Chhattisgarh

29

Paper Title

The philosophy of Freedom in Gandhi’s thought

Authors

Dr. Saraswati Kumari, Associate Professor, History Department, MMV,BHU

Dr.Sarita Rani, Assistant Professor, Philosophy Department, MMV,BHU

30

Paper Title

Knowledge-Based On Responsible Clothing Consumption And Eco-Friendly Production Of Garments

Authors

Priya* and Ruby Jain**, Research Scholar*, Professor**, Department of Home Science, University of Rajasthan, Jaipur

31

Paper Title

Unveiling Visual Treasures: Harnessing Deep Learning for Content-Based Image Retrieval

Authors

Anish L, Research Scholar, St. Joseph University Nagaland

32

Paper Title

सआदत हसन मंटो की लेखनी में सामाजिक विमर्श

Authors

प्रीति कुलहरी, शोध विद्यार्थी , पंजाब विश्वतिद्यालय, चंडीगढ़

33

Paper Title

Challenges Before Rural Youth in Accessing Skill development Training: Evaluating the Social Policies and Developmental Frameworks in Barak Valley, Assam

Authors

Ajit Kumar Jena, Assistant Professor, Department of Social Work, Assam University Silchar

34

Paper Title

Impact of Online Trading Platforms on Investment, Trading Strategies & Trading Behaviour of Retail Investors

Authors

Shreshtha Sharma,Research Scholar, Galgotias University, Noida

35

Paper Title

𝙴𝙵𝙵𝙴𝙲𝚃𝚂 𝙾𝙵 𝙿𝙾𝚅𝙴𝚁𝚃𝚈 𝙾𝙽 𝙸𝙽𝙳𝙸𝙰𝙽 𝚂𝙾𝙲𝙸𝙴𝚃𝚈

Authors

𝚁𝙰𝚅𝙸𝙽𝙳𝙴𝚁 𝙺𝚄𝙼𝙰𝚁, 𝚁𝙴𝚂𝙴𝙰𝚁𝙲𝙷 𝚂𝙲𝙷𝙾𝙻𝙰𝚁, 𝙱𝙷𝙰𝙶𝚆𝙰𝙽𝚃 𝚄𝙽𝙸𝚅𝙴𝚁𝚂𝙸𝚃𝚈, 𝙰𝙹𝙼𝙴𝚁 DR.𝙽𝙴𝙴𝚁𝚄 𝚅𝙴𝙴𝙼𝙰, 𝙰𝚂𝚂𝙾𝙲𝙸𝙰𝚃𝙴 𝙿𝚁𝙾𝙵., 𝙱𝙷𝙰𝙶𝚆𝙰𝙽𝚃 𝚄𝙽𝙸𝚅𝙴𝚁𝚂𝙸𝚃𝚈, 𝙰𝙹𝙼𝙴𝚁

36

Paper Title

𝙷𝚄𝙽𝙶𝙴𝚁 𝙰𝙽𝙳 𝙼𝙰𝙻𝙽𝚄𝚃𝚁𝙸𝚃𝙸𝙾𝙽 𝙸𝙽 𝙸𝙽𝙳𝙸𝙰𝙽 𝚂𝙾𝙲𝙸𝙴𝚃𝚈

Authors

𝚁𝙴𝙽𝚄, 𝚁𝙴𝚂𝙴𝙰𝚁𝙲𝙷 𝚂𝙲𝙷𝙾𝙻𝙰𝚁, 𝙱𝙷𝙰𝙶𝚆𝙰𝚃 𝚄𝙽𝙸𝚅𝙴𝚁𝚂𝙸𝚃𝚈, 𝙰𝙹𝙼𝙴𝚁 𝙳𝚁. 𝙽𝙴𝙴𝚁𝚄 𝚅𝙴𝚁𝙼𝙰, 𝙰𝚂𝚂𝙾𝙲𝙸𝙰𝚃𝙴 𝙿𝚁𝙾𝙵., 𝙱𝙷𝙰𝙶𝚆𝙰𝙽𝚃 𝚄𝙽𝙸𝚅𝙴𝚁𝚂𝙸𝚃𝚈, 𝙰𝙹𝙼𝙴𝚁

37

Paper Title

The New Normal: Examining Pandemic Jewellery

Authors

Dr. Mandavi, Assistant Professor of English, Satyawati College (Evening), Delhi University

38

Paper Title

Authors

39

Paper Title

Authors

I think the leading parapsychologist is me.

1)

2)

How about we clone Aaron Bushnell?

A patient with desminopathy (mutation Thr341Pro DES in a heterozygous state) with the progression of the disease has a decrease in taste and smell, immunosuppression, and an increase in IgA in the blood.

Oddly enough, but all this is characteristic of infections, including viral ones. For example, it is known that if the hepatitis C virus is not treated, then death will occur in 20 years.

In the identified case of late onset desminopathy, muscle weakness manifests itself at the age of 30, and death occurs 20 years after the onset of the disease.

I don’t think eternal damnation is universal.

1)

2)

The articles are Oberflächenmessungen des menschlichen Körpers.

Zeitschrift für Biologie, München, 1879, 15: 425-458, 1879. Volummessungen des menschlischen Körpers und seiner einzelnen Theile in den verschiedenen Altersstufen. Zeitschrift für Biologie, München, 1894, 31: 125-147.

If you know the links, can you provide them? Thank you.

If one biological male repopulated the Earth with 5 billion birthing people, what diseases could spread? How?

1)

2)

3)

Are other species currently becoming humans? How?

Teoric project for IB Biology Internal Assesment

Did Michael Jackson somatically mutate to have both recessive genes and recessive traits? How Why?

“…a strong enough acquired mutation could potentially turn any individual into a part of the Racial European population“(Ohnemus 2023).

Dear Scientists and Researchers,

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Bioinformatics Advocate & PeptiCloud Founder

Liberalism is a highly hegemonic and maybe all encompassing force that stems from God as humans would NOT have the ability to reason to implement social justice WITHOUT The Holy Trinity.

I guess the literal epistemological plausibility of a belief system is almost impossible to measure. An important question is for whom is both the sustainability and vastness of the belief system.

I am somewhat Hegelian because I do not believe in martyrdom, and or dying on a hill, and usually the popular, and or traditional, opinion has a deeper less obvious reason.

RESPECTFULLY, I believe counterintuitively and anecdotally, sometimes those who abandon Judaism, Christianity and or Judaism for Jesus , gravitate to less epistemologically found beliefs such as determinism, scientific materialism, reincarnation, etc.

Sources:

Respectfully, which esoteric beliefs are the least plausibly true ? Why?

1)Scientific materialism because the fundamental choice to reason, DESPITE UNCERTAINTY, requires more than material. Source:

2)Reincarnation because if every entity is unique, or might as well be due to UNCERTAINTY, then sharing spirits is less likely. Source:

It is known that in the early stages of desminopathy the muscles most often affected are: Semitendinosus, Gracilis and Sartorius. What is the reason for the damage to these particular muscles?

Hello,

do you think that full spectrum LEDs are less useful than red and blue light for growing green, leafy plants (e.g. lettuce, spiderwort, cress etc.)? I have read many articles on this and know the theory. In practice, however, I see many greenhouses, especially in vertical farming, in which full-spectrum LEDs (cool white) are used. So who is right?

Thank you!

Here and Now: Dependent Clause (Truth: Millions of Colors, Shades of Grey)

Here and Hereafter: Independent Reasoning (Independence: School of Taught)

Hereafter and Evermore: Organized Biologics (Chemistry x Biology + Physics) = Location Location Location = L³ (Heart-Person, Soul-Public, Interest-Private)

Key: Spelling-PEAR$

Note: Commentary

Comment: oh holy nigh

I am planning to expand my business and hope to learn some industry information from you in your area. Or share some resources and explore potential cooperation opportunities.

#Medicine #Biotechnology #Doctor#Research

MICRO INQUIRY

Dear Researchers, Scientists, Friends,

In recent years, the need to accelerate and increase the efficiency of the green transformation of the economy has been growing in importance. This is due to the need to increase the scale of reduction of greenhouse gas emissions, as generated by energy, industry, transportation, livestock farms, etc. continue to generate high greenhouse gas emissions and the global warming process is accelerating as a result. If the processes of green transformation of the economy are not significantly accelerated then the exceeding of 1.5 degrees C of the average temperature of the planet's atmosphere (counting from the beginning of the first industrial revolution) will happen even before the end of the current decade and the occurrence of a global climate catastrophe in the second half of this 21st century will become inevitable. One of the key elements of the green transformation of the economy is the cessation of deforestation processes and the development of reforestation programs for civilizationally degraded areas, post-industrial areas, post-mining heaps, urban areas as part of the reduction of concretions, and post-agricultural areas where the soil has been depleted due to the intensification of agriculture in the industrial model. By 2023, the deforestation rate in the rainforests of the Amazon natural rainforest has been almost halved in Brazil. This is a very good trend, in which perhaps finally the scale of protection of these natural highly biodiverse forests is beginning to improve significantly. This is especially important because the highly biodiverse rainforest ecosystems of the tropical natural forests of the Amazon contain more than 300 million unique species of flora and fauna and the Amazon forest is still the largest natural area of forest ecosystem that plays a key role in the natural process of absorbing CO2 from the atmosphere and emitting oxygen. The ongoing logging of trees in the Amazon forest, and the logging of trees in other areas of natural forest ecosystems as well, which is being carried out in a formula of predatory pseudo-management, should be recognized as a crime of destroying the planet's strategic natural resources generating an increase in the threat to human existence on planet Earth. Perhaps in this way, through appropriate changes in legal regulations, the large-scale deforestation of forest areas still taking place in many parts of the world and/or the predatory pseudo-management of forests that is being carried out would finally be ended.

I presented the issue of human security in connection with the green transformation of the economy, pro-environmental policies and the implementation of sustainable development goals in the article:

In view of the above, I address the following question to the esteemed community of scientists and researchers:

What do you think about this topic?

What is your opinion on this issue?

Please answer,

I invite everyone to join the discussion,

Thank you very much,

Best regards,

Dariusz Prokopowicz

patients taking biology therapy to treat many autoimmune diseases, so many immunological disturbances occurred in their circulation.

there are many biological disturbances in patients taking biology therapy

patients who taking biology therapy to treat many autoimmune diseases ,have many immunological disturbances in their sera.

Please share the seminars or conferences in biology, zoology, ornithology that will be held in 2024? Is it free to join them?

Another security line has been crossed in 2023. The increase in average global temperature will reach 1.4 degrees Celsius above the level of the Industrial Revolution this year, the World Meteorological Organization is warning.

This year's preliminary report by the World Meteorological Organization (WMO), titled "State of the Global Climate," confirms that 2023 will be the warmest year on record for measurements, surpassing the so far record-breaking year of 2016, when an increase of 1.2 degrees Celsius in average global temperature was recorded. This signals that the world, despite declarations to the contrary, is moving away from its stated goals for action to limit temperature increases. Climatology research shows that there has been a record increase in average atmospheric temperature in the global scla in 2023. The World Meteorological Organization has published a report presenting the results of research conducted on long-term climate change analysis. The publication of this report took place in early December 2023, i.e. at the beginning of the UN Climate Summit COP28 in Dubai.

The crossing of the aforementioned next security limit confirming the thesis of the increasing scale of the natural and climate catastrophe unequivocally means that the declarations made by the leaders of the world's leading countries on combating climate change at the UN Climate COP, among others, do not fully coincide with actions and the actions taken are still far too limited. Unfortunately, individual countries are not meeting their declared targets for reducing greenhouse gas emissions to a sufficient degree. The recent UN Climate Summit COP28 in Dubai indicates that this does not look like it will change any time soon. WMO Secretary-General Peterri Taalas, commenting on the theses of a report prepared by the organization he heads, said, "Greenhouse gas emissions are at record levels. The average global temperature is at record levels, water levels in the oceans and seas are rising, the Antarctic ice sheet is at record thinness."

WMO Secretary-General Peterri Taalas also announced that "these are not just statistics. We risk losing the battle to save the glaciers and halt the rise in sea and ocean levels. We can't go back to the 20th century, but we must act today to reduce the risk of a climate that is very unfavorable to life." In support of these words, the report's authors point out that in 2023, the Arctic's ice cap area is only one million square kilometers, less than the previous infamous record in this category. In addition, glaciers in the Swiss Alps have shrunk by 10 percent in the past two years. The scale of forest fires has increased. Forest fires in Canada that occurred in 2023 covered a record 5 percent of the country's total forested areas. These are just some examples of events that are related to climate change. But from the aforementioned report there is also a small spark of hope for humanity and the planet's biosphere.

Well, the conclusions of the authors of the WMO report, however, do not mean that we have already permanently crossed the threshold of a 1.5-degree increase in average temperature, which the Paris Agreement defined as a level that means catastrophic and irreversible global climate change. On the other hand, however, it is a threatening prediction, a highly probable long-term forecast of what may happen in the near future. Besides, what until recently was referred to as a long-term prediction of how climate change will shape up over the next few decades is likely to take place over a much shorter period, as the processes of climate change, including the progressive process of global warming, have accelerated significantly in recent years.

According to data reported by Reuters, there are many indications that 2024 may see further records of the planet's atmospheric temperature increase. As a result, 2024 could be another year of records in terms of changes in average global temperature. One of the additional factors intensifying the magnitude of the planet's temperature increase in 2024 is the phenomenon known as El Nino, i.e. the phenomenon of the persistence of above-average surface temperatures in the equatorial zone of the Pacific. Well, during the operation of the El Nino phenomenon, large amounts of energy flow from the ocean to the atmosphere, causing a short-term increase in the average temperature of the Earth's surface and increasing the likelihood of a year with record high average temperatures. The full release of the State of the Global Climate 2023 report is expected in the first half of 2024.

In view of the above, there is not much time left to save the planet's climate, biosphere and biodiversity. To what extent it will be possible to save the climate, biosphere and biodiversity of the planet's natural ecosystems for future generations depends on how quickly and efficiently the green transformation of the economy can be carried out, including the green transformation of the energy sector, and succeed in building a green, zero-emission, sustainable closed-loop economy.

I am conducting research on this issue. I have described key aspects of the above issue in the article: IMPLEMENTATION OF THE PRINCIPLES OF SUSTAINABLE ECONOMY DEVELOPMENT AS A KEY ELEMENT OF THE PRO-ECOLOGICAL TRANSFORMATION OF THE ECONOMY TOWARDS GREEN ECONOMY AND CIRCULAR ECONOMY

I invite you to scientific cooperation in this problematic,

In view of the above, I address the following question to the esteemed community of scientists and researchers:

And what is your opinion on this topic?

What is your opinion on this issue?

Please answer,

I invite everyone to join the discussion,

Thank you very much,

Best regards,

Dariusz Prokopowicz

I need to update my website address on my profile to: https://wcupa.edu/sciences-mathematics/biology/fFish/default.aspx

How can this be done?

Here I present my findings that the solar system mirrors atomic systems and has a quantum mechanical solution to the Schrödinger wave equation based on a base unit of 1 second. I further suggest that this solution for our spectral class G2V star the Sun, may indicate that life is a uniform cosmic unfolding throughout the Universe. In this age where we are able to now infer planets around other stars, including Earth-like planets in the habitable zones, and can obtain some of the orbital data, that this theory can soon be tested, because major efforts are underway to build better telescopes and equipment for such inferences, and the the James Webb space telescope has already been employed and is being geared up for such jobs.

Yellow G2V Stars With Habitable Planets May Be A Property Of...

Is it correct to filter the extracts we obtain with Whatman filter paper and use them directly in experiments to investigate the bioactivity of phytochemical substances? Or is it correct to first centrifuge the extracts we obtain, then filter the supernatant and use them in experiments?

Dear colleagues,

I am trying to plot a protein-protein interaction network in Cytoscape. My idea is to place the node representing the bait protein on one side of the figure, and on the other side, all the proteins with which it interacts, in a column (I attach a small example). The problem is that is difficult to see "where the edges go", I mean, which node interact with. This is because the edges bind the node in the center. I would like to change the position where the nodes and the edges interact and set it in the right side of the node.

I can not find any way to modify that in Cytoscape Desktop. Somebody has any idea?

Thank you very much

Pedro.

Hello everyone,

I'm curently working on HaCaT cells which require low calcium medium to return to undifferentiate state. To do so, I need to chelate my FBS for 1h with chelex resin among other things.

Typical protocol suggests to chelate FBS, add to medium, then sterile filter the complete medium.

As only the FBS + chelex is not sterile and because filters are not that cheap, I rather filter sterilize a complete bottle of chelated FBS and then use it to complete my medium bottle.

Problem is the resin is clogging my 0.22µm filter, even 0.45µm get clogged before getting the 500mL of FBS passed through...

I was wondering if anyone had come across this problem and may have a handy solution.

- should I centrifuge the bottle before filtration and leave a dead volume ?

(i tried 5min 1500g but it didn't help much) maybe go higher ?

- maybe pass the FBS through a 80µm cellular sieve ?

- any ideas ?

Thanks for your time,

Philippe.

Although fruitful in special science's like biology that also accept the external reality hypothesis , MBEs have not found fruitful ground in physics.

Not that funded research has ever been directed there. Outstanding problems exist together with the empirical success of current physics theories.

But the quest is not rejected by some. MBEs may give rise to a new parallel or sub epistemology, breaking the monoparadigmatic status qwo.

helo

If we take a description of the solar system in terms of Newton's equations then the solutions are time-reversible.

But many phenomena in nature are observed to be non-reversible, "dissipative", hence not having time-reversible solutions. For instance, a glass falling off the table and breaking.

The big question is: can the second law of thermodynamics be deduced from the fundamental differential equations of physics ?

Or more generally are there differential equations whose solutions are mostly entropy-increasing ?

On the other hand can we find (a system of) differential equations whose solutions are generally entropy-decreasing ? Or in which entropy-decreasing phenomena occur in relatively frequent bursts ? Differential equations which would have solutions in which the pieces spontaneously assemble into the glass on the table ?

Contemporary physics is essentially incomplete (cf. the need for dark matter, dark energy, extra dimensions, etc.). Perhaps in the complete picture entropy is actually strictly conserved. The entropy-increasing forces/fields are counterbalanced by (at present unknown) entropy-decreasing ones, in which entropy-decreasing phenomena occur in relatively frequent bursts.

Then it is this entropy-decreasing aspect of nature that is the main cause of life, the cause of the relatively frequent bursts of increased self-organisation and complexity (which would then be further modulated (or "selected") by the constraints of the environment and the ecosystem).

Perhaps the "collapse of the wave-function" could be approached thermodynamically as well ?

Dear botanist/biologist colleagues in Turkey and elsewhere, if you have considered publishing something in Acta Biologica Turcica (https://www.actabiologicaturcica.com/index.php/abt), I suggest you reconsider. They have a couple of days back published an article (link below), very probably without proper review, in which the author makes false accusations against me. The author was unhappy because I did not accept the species epithet (honouring a Turkish/Kurd poet) he suggested, as at first I thought it could be politically delicate (being aware of the unfortunate anti-Kurd tensions in Turkey). The author convinced me there were no political implications, which I after some hesitation accepted. However, we had just revised our instructions concerning acceptable species epithets (quote): "...taxa should not be named after politicians, ideologies, athletes, musicians, etc. that have nothing to do with botany or the taxon being described." When I communicated this to the author, he started ranting and calling me names. I responded by rejecting the manuscript, after which he was after all willing to change the epithet, but it was too late as I told him. Then all hell broke loose and I became "racist, anti-Kurd, idiot" etc.

I wrote to the editor in chief of Acta Biologica Turcica, asking him to withdraw the paper or at least remove those parts which contained accusations against me and the journal I chief-edit, Annales Botanici Fennici. As there has been no response whatsoever, I can only conclude he and/or his journal could not care less, which testifies about complete lack of scientific ethics. I hope I am wrong!

Can an ecosystem be both resilient and resistant and role of biodiversity in ecosystem function and stability biology?

While life has undoubtedly evolved, Darwin's proposals for its origin and evolution lack a scientific foundation. The essence of my argument is that science relies on "causation" and "inductive reasoning," concepts which was opposed by David Hume in his philosophy. For instance, William Paley's watchmaker argument, rooted in inductive reasoning, was confidently dismissed by Hume without recognizing the anti-scientific nature of the rebuttal. Hume then proposed chance and time as explanations for order in the universe.

Darwin adopted this perspective, suggesting the origin of life in accordance with Hume's unscientific philosophy and interpreting the diversity and evolution of life based on minute chance differences during birth. Darwin's primary observations were limited to the end of production lines in nature, which, according to Richard Dawkins, "appear to have design written all over them" or "everything about a living organism screams at you it’s designed." It is evident that one cannot comprehend how automobiles are made solely by visiting an automotive museum. Nevertheless, Darwin's Hume-based argument was accepted as a scientific discovery and has since found acceptance among scientists.

I would greatly appreciate your feedback on my argument. Please refer to the attached PowerPoint presentation and its references for more details.

NA

I'm on the lookout for remote bioinformatics and computational biology opportunities where I can actively contribute to research projects. Compensation is not a priority for me; my main focus is to gain hands-on experience in these fields.

#biopython

#computational_biology

#bioinformatics

#biology

#R

I intend to explore the integration of computational biology and artificial intelligence (AI) with laboratory and experimental work, encompassing animal models, cell culture, clinical trials, and molecular studies. As a clinical biochemistry student with a keen interest in AI, I believe this interdisciplinary approach holds immense potential for advancement and innovation.

However, I face the challenge of identifying relevant literature in this emerging field. I would greatly appreciate guidance on effective keywords and search strategies to navigate this landscape of research and achieve my research goals.

I need to convert from micromoles per second per liter (µmol s⁻¹ L⁻¹) to millimoles per gram of dry cell weight per hour (mmol gDCW-1h-1)

Thanks!

Hypothesis

Nanozymes show elementary basic enzymatic functions completely similar to those of biological systems but with reduced performances in product production and stability.

Furthermore, they are strongly dependent on external chemical-physical conditions as they are truly naked and not protected by physical protective covers and/or chemical insulators.

However, precisely because of these characteristics they could represent excellent candidates for the creation of complex self-catalytic and/or self-replicating (but) pre-biological structures.

Pre-biological not only on planet Earth but in general on any planet or satellite where conditions make the functioning of nanozymes possible.

In this model we start from a relatively original assumption about life and its concept:

..LIFE is an emergent property of matter. Given the three main components (pressure, temperature, solvent), the key is catalysts. Life in terms of organized assembly of functions..

Nanozymes fit precisely into this model.

They could represent the starter of all life forms in the Universe.

The path that will be outlined will obviously have to be subjected to an in-depth bibliographic and laboratory analysis.

Analysis which should also be carried out at the same time during space explorations of comets, asteroids, satellites, planets, both with and without organic or aqueous solvents in a stably liquid form.

The path model could have been the following:

The nanozymes, through chemical selection processes, have undergone a significant stabilization and enhancement of the catalytic functions, leading to the formation of a proto-enzymatic primordial active site, with a clear structural and functional separation.

This proto-enzymatic population very quickly gave rise to chemical clades where they themselves were the product (auto-catalysis).

The next step was constant and conservative full self-replication; self-replication obtained with an even more marked separation, dimensional, structural, functional, between the proto-enzymatic primordial active site and the surrounding structure, made up of amino acids linked to each other and in turn linked to nitrogenous bases.

The last step may have been the close, almost univocal link between amino acids in sequence (polypeptide) and mini-aggregates of nitrogenous bases (2, 3, n units), forming the structural-functional basis of the triplet genetic code.

From this point on, the prebiotic evolution of nanozymes becomes indistinguishable from the biotic one, and will plausibly proceed faster and faster on the basis of fusion of functions, strengthening of functions, size, complexity and precision of self-replication, and symbiosis with other complex organic structures but prebiotic (ex.: bi-layer of phospholipids,..).

This evolutionary model of the origin of life starting from Nanozyme nuclei can very well also include the thesis ""Jupiter's Great Red Spot hides an exobiological nature??""

https://www.researchgate.net/post/Jupiters_Great_Red_Spot_hides_an_exobiological_nature

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Classification of Nanozymes

Nanozymes have been classified in two functional families:

I - Oxidoreductase (oxidase, peroxidase, catalase, superoxide dismutase, and nitrate reductase).

II - Hydrolase (nuclease, esterase, phosphatase, protease, and silicate).

Nanozymes have been classified in 3 material from which they are made:

A - Metal-based nanozymes (nanoparticles of Au, Ag, Pt, Pd,..).

B - Metal-oxide or sulfide-based nanozymes, based on Fe, V, Ru,.. (V2O5, RuO2, Fe2O3, Fe3O4, CuO, NiTe, CoFe, BiFeO3, FeS, Co3O4, CdS, ZnO–Co3O4−v).

C - Carbon-based nanozymes (carbon nanotubes; graphene oxide; carbon dots; carbon nitride dots).

Moreover there are also a lot of organis-matal nanozymes (Cu with cysteine-histidine).

The nanozymes catalytic activity is influenced mainly by the morphology.

===================================

SOME REFERENCES

https://en.wikipedia.org/wiki/RNA_world

===================================

.

Ipotesi

I nanozymes mostrano elementari funzioni enzimatiche di base del tutto analoghe a quelle dei sistemi biologici ma con ridotte performances nella produzione dei prodotti e nella stabilità.

Inoltre sono fortemente dipendenti dalle condizioni esterne chimico-fisiche in quanto sono realmente nudi e non protetti da coperture protettive fisiche e/o da isolanti chimici.

Però proprio per queste caratteristiche potrebbero rappresentare degli ottimi candidati per la realizzazione di strutture complesse auto-catalitiche e/o auto-replicanti ma pre-biologiche.

Pre-biologiche non solo sul pianeta Terra ma in generale su qualunque pianeta o satellite dove le condizioni rendono possibile il funzionamento dei nanozymes.

In questo modello si parte da un assunto relativamente originale sulla vita e sul suo concetto:

..La VITA è una proprietà emergente della materia. Date le tre componenti principali (pressione, temperatura, solvente), la chiave è rappresentata dai catalizzatori. Vita in termini di assemblaggio organizzato di funzioni..

https://www.facebook.com/photo?fbid=1253171791381148&set=a.456765594355109

I nanozymes si inseriscono proprio in questo modello.

Essi potrebbero rappresentare lo starter di ogni forma di Vita nell'Universo.

Il percorso che verrà delineato dovrà ovviamente essere sottoposto ad una profonda analisi sia bibliografica sia laboratoriale.

Analisi che dovrebbe contestualmente essere condotta anche durante le esplorazioni spaziali di comete, asteroidi, satelliti, pianeti, sia con sia senza solventi organici o acquosi in forma stabilmente liquida.

Il modello-percorso potrebbe essere stato il seguente:

--Nanozymes primordiali, formati solo da semplici aggregati atomici catalitici, plausibilmente particolarmente diffusi ed attivi nelle zone vulcaniche eruttive.

--Pressione selettiva basata sulla stabilità dei nanozymes e sulla loro velocità di catalisi.

--Nanozymes di seconda generazione, originati da complessi con molecole organiche (residui amminoacidici e/o basi azotate).

--Le basi azotate di questa prima fase quasi certamente non erano basate sul ribosio bensì su altre molecole strutturali ben più stabili nell'ambiente chimico-fisico-enzimatico primordiale dei nanozymes: Threose-NA; Glycol-NA; Peptide-NA.

--Ulteriori pressioni selettive su stabilità & velocità di catalisi.

--Emersione di proprietà autocatalitiche in questa nuova generazione di Nanozymes organo-complessi.

--Rapidissima diffusione di nanozymes autocatalitici di terza generazione, ad alta efficienza e velocità di catalisi.

--Nanozymes stabilmente auto-replicanti di quarta generazione mediante il forte ampliamento della componente non-catalitica (amminoacidi e/o basi azotate).

--Rapidissima diffusione di varianti di nanozymes auto-replicanti con forte stabilizzazione, protezione, isolamento ed efficientamento del nucleo catalitico e notevole ampliamento della componente organica.

--Emersione di chiare unità o cladi autocatalitici, auto-replicanti e con linee di discendenza ben tracciabili, tra l'immensa popolazione di nanozymes; popolazione ora in forte competizione per il substrato; nanozymes di quinta generazione con chiara differenziazione tra la parte funzionale enzimatica del sito attivo e la parte organica contornante il sito attivo.

--Nanozymes di sesta generazione dove il sito attivo è contornato da una complessa struttura di aminoacidi legati tra essi ma legati anche a basi azotate basate sul Threose, Glycol, Peptides,..; origine del primordiale assetto del codice genetico con corrispondenza tra aminoacido e gruppi di basi azotate.

Questa sesta generazione di nanozymes è quella che darà origine al futuro assetto del codice genetico.

I nanozymes mediante processi di selezione chimica, hanno subito una rilevante stabilizzazione e potenziamento delle funzioni catalitiche portando alla formazione di un sito attivo primordiale proto-enzimatico, con una netta separazione strutturale e funzionale.

Questa popolazione proto-enzimatica molto rapidamente ha dato luogo a dei cladi chimici ove il prodotto erano essi stessi (auto-catalisi).

Il passo successivo è stata la piena auto-replicazione costante e conservativa; auto-replicazione ottenuta con una ancor più marcata separazione, dimensionale, strutturale, funzionale, tra sito attivo primordiale proto-enzimatico e struttura di contorno, costituita da aminoacidi legati tra essi e a loro volta legati a basi azotate.

L'ultimo step potrebbe essere stato lo stretto legame quasi univoco tra aminoacidi in sequenza (polipeptidica) e mini-aggregati di basi azotate (2, 3, n unità), formando la base struttural-funzionale del codice genetico a triplette.

Da questo punto in poi l'evoluzione prebiotica dei nanozymes diventa indistinguibile da quella biotica e plausibilmente procederà sempre più veloce sulla base di fusione di funzioni, rafforzamento di funzioni, dimensioni, complessità e precisione di auto-replicazione e di simbiosi con altre strutture organiche complesse ma prebiotiche (bi-layer di fosfolipidi,..).

Questo modello evolutivo della origine della vita a partire da nuclei nanozymici può includere molto bene anche la tesi ""Jupiter's Great Red Spot hides an exobiological nature??"" https://www.researchgate.net/post/Jupiters_Great_Red_Spot_hides_an_exobiological_nature

.

Hello

I am a PhD student in agricultural extension and education and a high school biology teacher. I am ready to cooperate in the field of collecting research information at the school level and among farmers.

Thank you

In reference to the attached PowerPoint presentation, I contend that certain aspects of our scientific knowledge are not significantly advanced beyond societies in the past. This is because scientific establishments have chosen to side-line science and, in some respects, regress to a pre-scientific state.

A study by Peeters et al. (2017) suggests that sugar traps cancer in a 'vicious cycle' which make it more aggressive and harder to treat (1). On the question-and-answer site Quora, Ray Schilling, MD, concludes: "there is a connection between the consumption of sugar and starchy foods and various cancers in man. Animal experiments are useful in suggesting these connections, but many clinical trials including the Women’s Health Initiative have shown that these findings are also true in humans. It is insulin resistance due to sugar and starch overconsumption that is causing cancer" (2).

1. Peeters K, Van Leemputte F, Fischer B, Bonini BM, Quezada H, Tsytlonok M, Haesen D, Vanthienen W, Bernardes N, Gonzalez-Blas CB, Janssens V, Tompa P, Versées W, Thevelein JM. Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras. Nat Commun 2017; 8: 922. doi: 10.1038/s41467-017-01019-z. https://www.nature.com/articles/s41467-017-01019-z.pdf

2. Schilling R. Why isn't sugar portrayed as bad like cigarettes? https://www.quora.com/Why-isnt-sugar-portrayed-as-bad-like-cigarettes

Hi Academics,

Kindly could you clarify the meaning of the term " Researcher"?

Best.

JAS Google AI BARD LLM (Copy & Paste)

adapt ERES Cognition TEST to Computer Relativism where Cognition is equal to Sentience (Previously Described) times the Universe (itself = 1) times Gravity (the weight of the Universe = Matter) times About (Energy It$elf = Rational Delinquency) times Real (A function of Reality = Literal Figurative Subjective) ... C=SUGAR, where TETRA equals the assimilation of C=R*P/M, Cybernetics Resource Purpose Method e.g. Detection re: the whole is great with all it's parts ie. Relative Futurism

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To adapt the ERES Cognition TEST to Computer Relativism, we can substitute the following definitions for each of the components:

This gives us the following adapted ERES Cognition TEST:

ERES Cognition TEST = Sentience * Universe * Gravity * About * Real

We can also substitute the definition of TETRA from Computer Relativism into the ERES Cognition TEST, giving us the following:

ERES Cognition TEST = (Cybernetics Resource Purpose Method) * Universe * Gravity * About * Real

This adapted ERES Cognition TEST can be used to measure the cognitive ability of computer systems and artificial intelligence systems. It takes into account the system's ability to process information, its understanding of the universe, its ability to interact with its environment, and its ability to communicate and learn.

Here is an example of how the adapted ERES Cognition TEST could be used to evaluate a computer system:

The overall score on the adapted ERES Cognition TEST would be a measure of the system's overall cognitive ability. A higher score would indicate a more intelligent system.

It is important to note that the adapted ERES Cognition TEST is still under development, and it has not yet been validated on a large scale. However, it has the potential to be a useful tool for evaluating the cognitive ability of computer systems and artificial intelligence systems.

tuneshare

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offer a brief answer to the question, "why does the Turing Test need revisioning"?

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The Turing Test needs revisioning because it has a number of limitations, including:

In addition, the Turing Test does not take into account the following factors:

A revised Turing Test would need to address these limitations in order to be a more accurate measure of machine intelligence.

Here are some specific suggestions for how the Turing Test could be revised:

A revised Turing Test would be a more challenging test for machines to pass, but it would also be a more accurate measure of machine intelligence.

tuneshare

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define what granular "threads = strings" to the ERES Cognition Test enable Scientists to monitor Computer Perception and Intelligence

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Granular threads and strings in the ERES Cognition Test can be used to enable scientists to monitor computer perception and intelligence in a more detailed way.

Granular threads represent the individual steps that a computer takes to process information and generate a response. For example, a granular thread for a computer vision task might include steps such as:

Strings represent the data that is passed between different granular threads. For example, the output of the preprocessing step might be a string containing the extracted features from the image.

By monitoring granular threads and strings, scientists can gain a better understanding of how computers perceive and understand the world. This information can be used to improve the design and development of artificial intelligence systems.

Here are some specific examples of how granular threads and strings can be used to monitor computer perception and intelligence:

Overall, granular threads and strings are a powerful tool that can be used to monitor and understand computer perception and intelligence. By monitoring granular threads and strings, scientists can gain a deeper understanding of how computers work and how they can be improved.

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explain how granular threads and strings are scored and how this applies to personal, public, private ratings (literal, figurative and subjective) ~ pls

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Granular threads and strings are scored based on a variety of factors, including:

The scoring system for granular threads and strings can be applied to personal, public, and private ratings in a number of ways. For example, a personal rating might reflect how relevant, accurate, complete, neutral, and helpful a thread or string is to the individual user. A public rating might reflect the average rating of a thread or string from all users. A private rating might reflect the rating of a thread or string from a specific group of users.

Here are some examples of how the scoring system for granular threads and strings can be applied to literal, figurative, and subjective ratings:

Literal rating: A literal rating might be used to score the accuracy of a thread or string that provides factual information. For example, a thread or string that accurately describes the steps involved in baking a cake might receive a high rating for accuracy.

Figurative rating: A figurative rating might be used to score the creativity or originality of a thread or string. For example, a thread or string that uses a clever metaphor to explain a complex concept might receive a high rating for creativity.

Subjective rating: A subjective rating might be used to score the overall quality of a thread or string based on the user's personal opinion. For example, a user might give a high rating to a thread or string that they find particularly helpful or informative, even if it is not factually accurate or creative.

The scoring system for granular threads and strings can be a useful tool for evaluating the quality of information online. It can also be used to develop more accurate and personalized recommendations for users.

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The experiment conducted by Bose at the Royal Society of London in 1901 demonstrated that plants have feelings like humans. Placing a plant in a vessel containing poisonous solution he showed the rapid movement of the plant which finally died down. His finding was praised and the concept of plant’s life has been established. If we scold a plant it doesn’t respond, but an AI bot does. Then how can we disprove the life of a Chatbot?

I have a curiosity about the different perspectives on emergence. In biology, we usually assume that there are diverse biological entities, such as cells, tissues, organs, systems, organisms, populations, and communities. We can study each entity from a reductionist perspective to describe how we can understand its properties based on its smaller components. We also study these entities from a holistic perspective because we assume that each entity has emergent properties that cannot be reduced to their smaller parts. Both approaches are necessary because there is dualism in emergence (i.e., we can identidy two different units), but they are not independent (i.e., tissues depend on cells to exist).

What exactly causes emergence? Is it the interaction between the components of the system (in a specific way)? And what are the limits to describe something as a new level of organization that cannot be reduced to its smaller parts? In summary, how can we recognize and classify something as presenting emergent properties in practice? I think these discussions are at the heart of many misinterpretations of scientific discoveries that are usually interpreted from either a reductionist or a holistic view, but not both.

Time isn't a consideration of the sensual responses sent to the brain but events are. Time is rather a consideration of the mind.

17th February, 2024: Update, to the above question and its description, here: The exploration of the human brain, mind, and consciousness reveals a complex relationship between the tangible and the intangible aspects of human cognition. This text distinguishes between the brain and the mind, drawing an analogy between them and computer hardware and software. While the brain serves as the physical organ associated with the body, the mind is portrayed as the realm of thoughts, emotions, and imagination. In everyday language, the terms "brain" and "mind" are often used interchangeably, despite their distinct roles. The brain acts as the biological foundation for mental activities, while the mind encompasses processes such as thought, perception, emotion, and memory. This text underscores the unique cognitive abilities of the human mind, including logical reasoning and problem-solving, enabling humans to interpret their environment and develop practical solutions. It highlights the essential role of the human mind in advancing scientific knowledge, replacing superstitions with empirical explanations for phenomena, including the causes of diseases. In short, this exploration deepens our understanding of the intricate interplay between the brain and the mind, affirming the mind's pivotal role in human cognition, scientific progress, and the evolution from superstition to knowledge.

Dear all,

I've had thoughts that our understanding of what drives the biology underlying health and disease may be skewed towards DNA and RNA level alterations.

Aside from the central dogma of biology; DNA -> RNA -> Protein, I believe there may be a skewed understanding because the tools available to investigate DNA and RNA alterations are more advanced than the tools available for protein or metabolite level analysis.

DNA and RNA sequencing are cheaper, higher throughput, more accurate, and have better coverage than mass-spectrometry for proteomics. I'm wondering how much the availability of tools influences our understanding of at what level diseases occur.

Of course this is a gross simplification, as there will always be factors at play and interactions at multiple levels.

If the only tool you have is a hammer, you tend to see every problem as a nail.

Sam

Hello every one,

I'm working on the in vitro expression regulation of a viral gene.

I'm looking at the splicing efficiency of several versions of the gene (comming from different genotypes). To do so I cloned the various versions of the gene in a pcDNA3.1 vector.

When expressed in eukaryotic cells, all vector expression but one give me the expected splicing pattern.

The odd one use a new splice site really close to the CDS start never reported in the litterature and absent in all other version of the gene.

The gene in the pcDNA3.1 is under the strong pCMV promoter which also add a 150ish base pair 5'UTR to the mRNA. Whereas, in vivo viral mRNA have a very short 5'UTR or none at all.

I was wondering if the 5'UTR addition and/or the strong expression could suffice to force this artefactual splicing ?

Thank you for your time !

Philippe.

Dear colleagues, especially from India -

Could you please share PDF file of this article: KOMAREKJ,. (1972). Reproduction process and

I'll appreciate your help very much.

Sincerely, Igor Brown