Jammula Sruti's research while affiliated with Roland Institute of Pharmaceutical Sciences and other places
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Publications (30)
In the pursuit of environmental sustainability, the field of green chemistry has emerged as a beacon of hope, offering innovative solutions to mitigate the ecological impact of chemical processes. This abstract explores the symbiotic relationship between green chemistry principles and sustainable practices, elucidating their pivotal role in fosteri...
Medicinal chemistry, at the nexus of chemistry, biology, and pharmacology, continually evolves to address the dynamic landscape of human health challenges. This abstract provides a succinct overview of emerging trends shaping the field of medicinal chemistry, highlighting key advancements, methodologies, and applications that hold promise for revol...
PurposeThe objective of the current research is to formulate a nanoemulsion (NE) of nimodipine (ND) to improve its oral bioavailability and stability by adopting a scientific and systematic quality-by-design (QbD) approach.Methods
Triacetin (oil), Cremophor RH40 (surfactant), and PEG600 (co-surfactant) were selected to formulate NE. Factors affecti...
Background
Cinacalcet HCl, a calcimimetic, BCS class IV drug with low oral bioavailability. Polymeric nanoparticles are widely used as biomaterials owing to their biocompatibility, biodegradability, varied structures, low toxicity, simple and easy formulation process.
Objective
To enhance the oral bioavailability of poorly water soluble drug i.e.,...
Currently, the COVID-19 pandemic appears to be the biggest challenge to man, claiming over 600,000 lives within 7 months. Various diagnostic kits for COVID-19 have emerged which is important in keeping track of the escalation of the disease. The World Health Organization has implored health agencies time and again to make the test for the novel cor...
Green chemistry is also referred as sustainable technology which involves the design, synthesis, processing and use of chemical substances by reducing or eliminating the chemical hazards. This strategy focuses on atom economy, use of safer solvents or chemicals, use of raw materials from renewable resources, consumption of energy and decomposition...
The key objective of the current research was to fabricate and optimize Capecitabine (Cap)-loaded [poly(lactic-co-glycolic acid)] PLGA-based nanoparticles (NPs) by enabling quality by design (QbD) approach for enhancing antitumor activity by promising delivery of the drug at the colonic site. The current research was based on fabricating PLGA-based...
The immune system involves both active and passive immunization. The antibodies are devloped against the antigens during active immunization and are permanently stored. But, in case of passive immunization, the antibodies are exposed to the same antigens in every person who are already infected. In order to enhance the immune systems i.e. innate an...
Drug repurposing is also termed as drug repositioning or therapeutic switching. This method is applied to identify the novel therapeutic agents from the existing FDA approved clinically used drug molecules. It is considered as an efficient approach to develop drug candidates with new pharmacological activities or therapeutic properties. As the drug...
Background:
Deep rooted mission for long life and having a sound skin has apparently achieved uncommon statures in our time of stamped populace maturing, aging alludes to the different procedures of mileage that influence us ceaselessly. Therefore, three primary ideal models such as ‘packed dismalness’, ‘decelerated maturing’ and ‘captured maturing...
Hypertension in children, although an uncommon entity, is associated with end-organ damage. We tried to study the clinical profile of hypertension in children presented to our hospital. The medical records from January 1990 to December 2010 of all children aged 18 years and younger with hypertension were studied. The patients were divided into four...
A combination of melt-granulated dispersion and surface adsorption techniques was used to enhance the dissolution and tableting properties of cefuroxime axetil (CA). Gelucire 50/13 was used as the melt-dispersion carrier and Sylysia 350 was used to adsorb the melt dispersion. Solubility studies showed an 8-fold increase in solubility at a ratio of...
Proteins and peptides are the building blocks of human body and act as the arsenal to combat against the invading pathogenic organisms for treatment and management of diseases. Majority of such biomacromolecules are synthesized by the human body itself. However, entry of disease causing pathogens causes misleading in the synthesis of desired protei...
A combination of fusion and surface adsorption techniques was used to enhance the dissolution rate of cefuroxime axetil. Solid dispersions of cefuroxime axetil were prepared by two methods, namely fusion method using poloxamer 188 alone and combination of poloxamer 188 and Neusilin US2 by fusion and surface adsorption method. Solid dispersions were...
The objective of the present research was to study the effect of two different types of polymer such as HPMCK4M and Eudragit RS 100 in formulation of a sustained release (SR) matrix tablet of stavudine. Stavudine and polymer compatibility studies were performed using Fourier transform infrared spectroscopy (FT-IR) and Differential scanning calorime...
Since decades tuberculosis remains unambiguouslya major health care problem in this world Osmotic drug delivery system utilizes the principles of osmotic pressure for the controlled delivery of active pharmaceutical ingredient at a predetermined zero order rate. An appropriately designed osmotic drug delivery is not influenced by different physiolo...
The work was aim to design and characterize the sustained release mucoadhesive microspheres of Tolterodine tartrate prepared by non-aqueous solvent evaporation technique using ethyl cellulose based selected mucoadhesive polymers. Selected microspheres formulations of were found to be discrete, spherical and free flowing from the preliminary formula...
Hypertension is a major risk factor for various macro and microvascular complications in a patient with diabetes. Control of hypertension is of paramount importance in the care of a diabetes subject. The goals for blood pressure in diabetes subjects are below 130/ 80 mmHg and below 125/75 mmHg if accompanying renal impairment is there. Spironolacto...
The current work aims to prepare the solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride (ONH) to enhance its oral bioavailability by improving its aqueous solubility and facilitating its absorption though lymphatic pathways. Preformulation studies including screening of excipients for solubility and pseudoternary phase diagra...
Pharmaceutical research and inventions are increasingly developed for the design of an ideal dosage regimen in drug therapy of many diseases, which attains therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment and also minimizes the side effects. Recent trends in pharmaceutical technology indicat...
A porous carrier sylysia 350 was used to enhance the dissolution properties of poorly soluble Cefuroxime Axetil (CA). Solid dispersions were prepared by solvent evaporation method using various ratios of CA–Sylysia 350. Evaluation studies like solubility, drug content, percentage yield, flowability, compressibility, Fourier transform Infrared (FT-I...
The objectives of present work was to design and characterize the rabeprazole sodium loaded microcapsules prepared by solvent evaporation technique using ethyl cellulose (EC) based various mucoadhesive polymer, followed by a triple coating with Eudragit L100. The Box-behnken design (BBD) was applied for optimization of formulations containing EC, H...
Pheochromocytomas have been described to be associated with rare vascular abnormalities, most common of them being renal artery stenosis. A 45-year-old woman was admitted to our hospital with complaints of headache, sweating, anxiety, dizziness, nausea, vomiting and severe hypertension. Hypertension was confirmed to result from both excess catechol...
Development of Solid Self-Nanoemulsifying Granules (SSNEGs) of Ondansetron Hydrochloride with Enhanced Bioavailability Potential, Colloids and Surfaces B: Biointerfaces (2010), doi:10.1016/j.colsurfb.2012.06.031 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this e...
Floating multi-particulate system for Repaglinide was prepared by melt granulation method using Gelucire 43/01 as the binder. Inclusion in 1:1 complex ratio of β-CD and HP-β-CD enhanced the solubility of Repaglinide by 4 to 5 folds. In vitro release studies, using release modulators such as HPMC K4M, HPMC K15M, HPMC K100M and ethyl cellulose (20cPs...
Oral controlled release systems are designed to release the drug in-vivo with prediction so as to increase efficacy, minimize adverse effects and increase bioavailability of drugs. Floating drug delivery systems (FDDSs) are expected to remain buoyant in a lasting way upon the gastric contents. The various buoyant preparations include hollow microsp...
The Purpose of this study was to prepare and characterize solid dispersions of this antiarrhythmic drug Verapamil hydrochloride (VPH) with HPMCK4M, EudragitRSPO and their combination with a view to sustain its dissolution properties. Investigation of the properties of the prepared solid dispersions were performed using release studies and Fourier t...
Mucoadhesive tablets of didanosine, a nucleoside analog used in the treatment of acquired immune deficiency syndrome (AIDS), have been developed employing carbopol 934P as a mucoadhesive polymer and HPMC-K4M, Na-Alginate and Na-CMC are the rate controlling polymers. Nine formulations of matrix (F1-F9) tablets were prepared by direct compression inc...
Direct tabletting technique is the most easy and simplest way of making tablets. Good flowability and compressibility is prerequisite for drug to be prepared by direct compression. There are several techniques available to impart desired compressibility to drugs. Spherical crystallization techniques are the promising techniques in which the drug cr...
Citations
... These constituents establish a comprehensive framework that steers the development and enhancement of NEM, ensuring their appropriateness for particular applications. Core elements include determining the distribution of droplet sizes, specifying stability parameters covering physical and chemical attributes, and establishing the zeta potential to influence electrostatic repulsion for overall stability [23]. In the realm of pharmaceuticals, the QTPP outlines aspects like drug loading and release kinetics, ensuring precise and controlled delivery. ...
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... The current study was approved by IAEC (proposal no 103) of RIPS (Regd.No.926/PO/ac/06/CPCSEA). Serum samples were centrifuged, the supernatant was collected and extracted with diethyl ether, the dry extract was diluted with mobile phase, and finally, the ND content was estimated at [34,35]. ...
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... It is an enveloped (+ss) RNA betacoronavirus whose genomes encode several accessory proteins, structural proteins, and non-structural proteins (nsps) [3]. Most people have a moderate infection, but the elderly or those who have underlying medical conditions, including cancer, diabetes, cardiovascular disease, or chronic respiratory disease, are more likely to experience a serious sickness that can lead to pneumonia, respiratory distress, and organ damage [4]. Most nations throughout the world have implemented extremely limited safety measures that are insufficient to stop the COVID-19 virus waves from spreading. ...
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... The zeta potential is a crucial parameter that acts as a fundamental indicator of the stability of colloidal systems. 21 The observed phenomenon manifests the electrostatic forces operative among particles inside a dispersion. The formulation's stability is attributed to preventing particle aggregation by electrostatic repulsion when the zeta potential falls within the ±20 to ±50 mV range. ...
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... Ramipril was tapped using USP tapped density tester (Electro labs, ETD 1020, Mumbai, India) 100 times in a cylinder, and the change in volume was measured. Carr's index and Hausner's ratio were calculated using equations 1 and 2 (Rao et al., 2011). ...
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... 100 mg of microspheres are been agitated for 5 min in 20 ml of pH 7.4 phosphate buffer prior filtering through a 0.45 m membrane filter. The overall drug content was estimated by spectrophotometric analysis, which shows the quantity of drug contained within formulations [17]. ...
... One of the main methods used to synthesize hierarchical crystals is the anti-solvent method [22][23][24][25]. Anti-solvent precipitation usually results in the crystallization of nanosized organic particles with controlled size and morphology. ...
... /100 g polymer) of such groups than ERS (25 mEq. /100 g polymer) (Patra et al., 2011;Mukund et al., 2012;Kawatra et al., 2012). As a result of the incorporation of esterified quaternary ammonium functional groups, ERS & ERL possesses a defined swelling capacity and permeability with respect to water which is independent of pH (Ramteke et al., 2012;Kaur Dupinder et al., 2012). ...
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... An FTIR spectrum of drug, excipients and drug-excipients mixture was recorded for the determination of drug interaction with excipients. Infrared spectrum was recorded in the 4000-400 cm −1 region [13]. ...
... Regarding poloxamer 188, the thermogram showed a sharp endothermic peak at Tm value of 54.89°C [52][53][54]. The physical mixtures containing these ingredients showed the same endothermic peak indicating no interaction and proving the existence of the drug in its crystalline form. ...
