Nawar Naseer's research while affiliated with University of Pennsylvania and other places

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Publications (4)

Fig. 1 Density (A) and prevalence plot (B) according to the PRS...
Fig. 2 Significance plot for all phenotypes for POAG PRS, grouped by...
Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks
Article
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  • Apr 2024
Background Glaucoma is a leading cause of worldwide irreversible blindness. Considerable uncertainty remains regarding the association between a variety of phenotypes and the genetic risk of glaucoma, as well as the impact they exert on the glaucoma development. Methods We investigated the associations of genetic liability for primary open angle g...
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Chi-squared and p-values from pairwise chi-square testing for clinical...
Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis
Article
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  • Jan 2024
The objective of this study is to define CT imaging derived phenotypes for patients with hepatic steatosis, a common metabolic liver condition, and determine its association with patient data from a medical biobank. There is a need to further characterize hepatic steatosis in lean patients, as its epidemiology may differ from that in overweight pat...
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Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection
Article
  • Sep 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated individuals is increasingly common but rarely results in severe disease, likely due to the enhanced potency and accelerated kinetics of memory immune responses. However, there have been few opportunities to rigorously study early recall responses during human viral...
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Figure 1. Recruitment and Demographics. (A) Distribution of enrollment...
Figure 2. Prevalence of diagnoses code among PMBB participants grouped...
Figure 4. A laboratory-wide association between mean body mass index...
Figure 5. Manhattan plot showing association between common genetic...
Clinical Data Availability for PMBB Participants.
The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population
Article
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  • Nov 2022
The Penn Medicine BioBank (PMBB) is an electronic health record (EHR)-linked biobank at the University of Pennsylvania (Penn Medicine). A large variety of health-related information, ranging from diagnosis codes to laboratory measurements, imaging data and lifestyle information, is integrated with genomic and biomarker data in the PMBB to facilitat...
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Citations

... Furthermore, we found T cell levels to be the single most predictive factor. Notably, it is the anamnestic T cell response that is the earliest during a breakthrough infection 30 . Moreover, the nAbs produced after booster vaccination are well below those in children with VVI(S) hybrid immunity, which is the only group with antibody titers above the threshold associated with protection from symptomatic infection. ...
Reference: Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children
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... The UKB is composed of >500,000 participating individuals aged 37-73 years at the time of recruitment, who underwent various questionnaires, physical measurements, biological sampling (blood and urine), and genome sequencing across 22 assessment centers in the UK 30 . A subset of participants were invited to complete an additional examination that included magnetic resonance imaging of the heart 10 .The PMBB is composed of 174,712 consenting patients of the Penn Medicine health network, with a subset of 44,000 participants with available genotyping data 11 . Additionally, all participants medical records including imaging results are de-identified and linked to their identifier. ...
Reference: Three-dimensional aortic geometry: clinical correlates, prognostic value and genetic architecture
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