Songshu Xiao's research while affiliated with The Third Xiangya Hospital of the Central South University and other places

... Currently, platinumbased chemotherapy is the mainstream treatment for OC [7]. Although improved surgical techniques and intensive chemotherapy regimens have improved survival in patients with advanced OC over the past two decades, treatment with non-selective cytotoxic drugs often results in severe toxic effects and transient antitumor responses [8]. Additionally, neurotoxicity, neuropathy, and cardiomyopathy caused by chemotherapy are common side effects that affect the normal life of OC patients [9]. ...

... SPs are a new type of simulated patient characterized by their ability to mimic the progression and reactions of real patients, thus integrating academic knowledge with clinical practice [16,17]. They have been widely used in clinical internships and have achieved good teaching results [18,19]. The combined application of SPs with other teaching methods, such as PBL, CBL, and mind mapping, has also further improved teaching effectiveness [20,21]. ...

... Newer lower cost manual mHTR devices have come on the market with previous studies confirming their efficacy in hysteroscopic polypectomy [13][14][15]. Nonetheless, head-tohead comparisons with the resectoscope, cold-knife resection, and elecromechanical mHTR devices are limited. This includes a recent report that compared the electromechanical mHTR to the Resectr™ 3 mm (Minerva Surgical, Inc., Sanat Clara, CA, USA) manual mHTR, and overall, it was non-inferior to the electromechanical mHTR (TruClear™, Medtronic, Minneapolis, MN, USA) for hysteroscopic polypectomy when comparing procedure duration, conversion rates, and incomplete resection rates, including a 10% reduction in average instrument setup time and a 30% increase in average removal time. ...

... The results, as shown in Figure 2B, showed that there was a significant difference in the expression of SKA1 between cancerous and paracancerous tissues (P=0.015). Many previous studies have demonstrated the important role of SKA1 in the malignant transformation and progression of multiple cancer types, because this gene can regulate various signaling pathways to affect tumor cell growth and metastasis [6]. Increasing clinical evidence has indicated that poor clinical prognosis, tumor invasion, and metastasis are all connected to increased SKA1 expression in a wide variety of cancers, including non-small cell lung cancer, bladder cancer, and hepatocellular carcinoma [7][8][9]. ...

... In the present case, the patient had a retroperitoneal ectopic pregnancy with natural conception. This may be a rare occurrence since almost all cases have been reported relative to IVF treatment [16][17][18]. Retroperitoneal implantation of a fertilized ovum may be primary or secondary to a ruptured EP originating at another site. However, an original tendency of embryonic location alongside the great blood vessels and invasion into the lymph node tissue has been found in some cases [9,18]. ...

... Minichromosome maintenance complex (MCM) genes play important roles in the process of DNA replication and cell cycle. MCM2 belongs to MCM family and participate in the regulation of cell proliferation and the development of cancers [45]. Elevated MCM2 has been found in pan-cancer and is associated with TMB, stage, immunotherapy response and dismal prognosis, indicating that MCM2 acts as a potential target for cancer immunotherapy [45]. ...

... Recently, T Cell Differentiation Protein 2 (MAL2) emerged as a potential driver of cancer immune escape and novel therapeutic target [7]. MAL2 was overexpressed in tumors and was associated with poor prognosis, and MAL2 knockdown improved major histocompatibility complex type 1 (MHC-1) recognition on tumor surfaces by CD8 + T cells, highlighting the role of MAL2 in immune regulation [8][9][10][11]. While the exact mechanism remains unknown, reducing MAL2 expression may be a novel therapeutic approach. More research is needed to fully understand the protein potential. ...

... Upregulation of NCAPH expression was significantly associated with hypomethylation [54]. Hua and colleagues used a variety of databases to describe a series of changes in MCM in EC, and they concluded that the mRNA and protein levels of MCMs were greatly increased in individuals with EC, while the average methylation level in the promoter region of MCM was dramatically reduced [55]. ...

... Although these studies included a large number of patients (sample sizes between 340 and 8,670), we did not include these studies as the exact follow-up moment between ablation and hysterectomy was unknown. [66][67][68][69] A reason for the increasing rate of hysterectomy rate over the years may be linked to regrowth of endometrial tissue, which can result in recurrent vaginal bleeding. Beelen et al 70 shows that especially patients who have an ablation at a young age (younger than 45 years) have a higher risk of experiencing recurrent vaginal bleeding. ...

... Although this approach can achieve complete remission in most patients, unfortunately, due to inherent/acquired drug resistance and severe adverse side effects, most patients are intolerant or refractory to platinum-based chemotherapy, resulting in low overall survival (6). Tumor cell spread and drug resistance lead to tumor relapse, thereby causing psychological and physical harm (7). Natural products from plants or their derivatives are critical sources of anti-tumor drugs, such as vincristine, vincaleukoblastinum, irinotecan, and topotecan, etc., which are provided with unique advantages owing to their multi-target function, extensive availability and long application history (8,9). ...